PMID- 24350300
OWN - NLM
STAT- MEDLINE
DCOM- 20140616
LR  - 20211021
IS  - 2314-6745 (Print)
IS  - 2314-6753 (Electronic)
VI  - 2013
DP  - 2013
TI  - Relevance of plasma obestatin and early arteriosclerosis in patients with type 2 
      diabetes mellitus.
PG  - 563919
LID - 10.1155/2013/563919 [doi]
LID - 563919
AB  - We investigated the correlation between obestatin and metabolic parameters and 
      carotid intima-media thickness (IMT) in plasma of patients with type 2 diabetes 
      mellitus (T2DM). We collected 103 patients aged from 60 to 83 years (69.26 +/- 5.83 
      years) form January, 2007 to May, 2009. All patients were divided into normal 
      glucose tolerance (NGT), impaired glucose tolerance (IGT), and T2DM according to 
      the oral glucose tolerance test (OGTT). We found that higher levels of fasting 
      insulin (Fins), fasting blood glucose, 2 h OGTT glucose, homeostasis model 
      assessment of insulin resistance (HOMA-IR), low density lipoprotein cholesterol, 
      glycated haemoglobin, and C-reactive protein (CRP), as well as lower obestatin 
      level and higher intima-media thickness level (IMT), existed in T2DM group 
      compared with NGT group and IGT group (P < 0.01). Also, obestatin level was 
      independently associated with HOMA-IR and CRP, while IMT level was independently 
      associated with HOMA-IR, triglyceride, Fins, and obestatin (P < 0.01), based on 
      stepwise multiple regression analysis. Therefore, we deduced that the low level 
      of plasma obestatin might be related to early arteriosclerosis in patients with 
      T2DM via increasing IMT level, and elevated plasma obestatin levels might protect 
      T2DM patients against carotid atherosclerosis to some extent.
FAU - Gu, Peng-Ying
AU  - Gu PY
AD  - Department of Geriatric Medicine, Anhui Provincial Hospital Affiliated to Anhui 
      Medical University, Hefei, Anhui 230001, China.
FAU - Kang, Dong-Mei
AU  - Kang DM
AD  - Department of Geriatric Medicine, Anhui Provincial Hospital Affiliated to Anhui 
      Medical University, Hefei, Anhui 230001, China.
FAU - Wang, Wei-Dong
AU  - Wang WD
AD  - Department of Geriatric Medicine, Anhui Provincial Hospital Affiliated to Anhui 
      Medical University, Hefei, Anhui 230001, China.
FAU - Chen, Yan
AU  - Chen Y
AD  - Department of Endocrine Laboratory, Anhui Provincial Hospital Affiliated to Anhui 
      Medical University, Hefei, Anhui 230001, China.
FAU - Zhao, Zhi-Hong
AU  - Zhao ZH
AD  - Department of Ultrasonic Medicine, Anhui Provincial Hospital Affiliated to Anhui 
      Medical University, Hefei, Anhui 230001, China.
FAU - Zheng, Hui
AU  - Zheng H
AD  - Department of Clinical Laboratory, Anhui Provincial Hospital Affiliated to Anhui 
      Medical University, Hefei, Anhui 230001, China.
FAU - Ye, Shan-Dong
AU  - Ye SD
AD  - Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui 
      Medical University, Hefei, Anhui 230001, China.
LA  - eng
PT  - Journal Article
DEP - 20131117
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Ghrelin)
RN  - 0 (obestatin, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carotid Artery Diseases/*blood/diagnostic imaging
MH  - Carotid Intima-Media Thickness
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/diagnostic imaging
MH  - Diabetic Angiopathies/blood/diagnostic imaging
MH  - Disease Progression
MH  - Female
MH  - Ghrelin/*blood
MH  - Glucose Intolerance/blood/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
PMC - PMC3855972
EDAT- 2013/12/19 06:00
MHDA- 2014/06/17 06:00
PMCR- 2013/11/17
CRDT- 2013/12/19 06:00
PHST- 2013/05/22 00:00 [received]
PHST- 2013/09/04 00:00 [revised]
PHST- 2013/09/10 00:00 [accepted]
PHST- 2013/12/19 06:00 [entrez]
PHST- 2013/12/19 06:00 [pubmed]
PHST- 2014/06/17 06:00 [medline]
PHST- 2013/11/17 00:00 [pmc-release]
AID - 10.1155/2013/563919 [doi]
PST - ppublish
SO  - J Diabetes Res. 2013;2013:563919. doi: 10.1155/2013/563919. Epub 2013 Nov 17.