PMID- 2435057
OWN - NLM
STAT- MEDLINE
DCOM- 19870422
LR  - 20190714
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 157
IP  - 2
DP  - 1987 Apr
TI  - Sequence relationships of type D retroviruses which cause simian acquired 
      immunodeficiency syndrome.
PG  - 317-29
AB  - Simian acquired immunodeficiency syndrome (SAIDS) in macaque monkeys is caused by 
      type D retroviruses; three independent virus isolates are identified as SRV-1 
      (SAIDS retrovirus-serotype 1), SRV-2, and MPMV (Mason-Pfizer monkey virus). 
      Virions from these three isolates have serologically related core antigens, but 
      distinct surface proteins. Also, SRV-2 is unique since it apparently induces 
      retroperitoneal fibromatosis in addition to SAIDS. The complete DNA sequence of 
      molecularly cloned SRV-2 is presented and compared to the sequences of SRV-1 and 
      MPMV and to the sequences of other retroviruses and retroviral-related elements 
      in the genomes of eucaryotic cells. SRV-1 and MPMV show fewer than 6% differences 
      in predicted amino acid sequences encoding gag, prt, pol, and the C-terminal env 
      domain; SRV-2 displays about 15-18% differences in these regions when aligned 
      with SRV-1 or MPMV. Greater variation of predicted amino acid sequences is noted 
      in the externally located N-terminal env domains; SRV-1 and MPMV have 83% 
      homology whereas SRV-2 has 58% homology with either SRV-1 or MPMV. Nucleotide 
      sequences of the LTRs of SRV-1 and MPMV are 88% homologous; SRV-2 shows 70% 
      homology with the LTRs of SRV-1 and MPMV. Comparisons of the predicted pol region 
      amino acid sequences of these simian type D retroviruses with the pol gene of a 
      type B retrovirus, mouse mammary tumor virus (MMTV), reveal about 50% homology. A 
      human endogenous element related to the pol region of MMTV shows about 25% 
      homology of amino acids with the pol sequences of SRV-1 or SRV-2. The prt genes 
      of the simian type D retroviruses are similar in size and predicted amino acid 
      sequence with the prt genes of MMTV and the hamster intracisternal type A 
      particle genome. The C-terminal env domains of the avian type C retrovirus 
      reticuloendotheliosis virus (REV) and the type C baboon endogenous virus (BaEV) 
      have 60 and 85% predicted amino acid homology, respectively, with the C-terminal 
      env domains of SRV-1, SRV-2, and MPMV. Within the gag and pol genes of the simian 
      type D retroviruses there are striking homologies with the rat IgE-binding 
      protein gene. Sequence relatedness of these type D retroviruses with type A, type 
      B, and type C retrovirus genomes and with cellular sequences supports the notion 
      that recombinational events contribute to the genesis and variation of 
      retroviruses.(ABSTRACT TRUNCATED AT 400 WORDS)
FAU - Thayer, R M
AU  - Thayer RM
FAU - Power, M D
AU  - Power MD
FAU - Bryant, M L
AU  - Bryant ML
FAU - Gardner, M B
AU  - Gardner MB
FAU - Barr, P J
AU  - Barr PJ
FAU - Luciw, P A
AU  - Luciw PA
LA  - eng
SI  - GENBANK/M16605
GR  - AI20573/AI/NIAID NIH HHS/United States
GR  - CA37467/CA/NCI NIH HHS/United States
GR  - RR00169/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (DNA, Viral)
RN  - 0 (Gene Products, gag)
RN  - 0 (Retroviridae Proteins)
RN  - 0 (Viral Envelope Proteins)
RN  - EC 2.7.7.49 (RNA-Directed DNA Polymerase)
RN  - EC 3.1.- (Endonucleases)
RN  - EC 3.4.- (Peptide Hydrolases)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/microbiology/veterinary
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA, Viral/genetics
MH  - Endonucleases/genetics
MH  - Gene Products, gag
MH  - *Genes, Viral
MH  - Macaca
MH  - Monkey Diseases/microbiology
MH  - Peptide Hydrolases/genetics
MH  - RNA-Directed DNA Polymerase/genetics
MH  - Repetitive Sequences, Nucleic Acid
MH  - Retroviridae/*genetics
MH  - Retroviridae Infections/microbiology/veterinary
MH  - Retroviridae Proteins/genetics
MH  - Sequence Homology, Nucleic Acid
MH  - Viral Envelope Proteins/genetics
EDAT- 1987/04/01 00:00
MHDA- 1987/04/01 00:01
CRDT- 1987/04/01 00:00
PHST- 1987/04/01 00:00 [pubmed]
PHST- 1987/04/01 00:01 [medline]
PHST- 1987/04/01 00:00 [entrez]
AID - 10.1016/0042-6822(87)90274-1 [doi]
PST - ppublish
SO  - Virology. 1987 Apr;157(2):317-29. doi: 10.1016/0042-6822(87)90274-1.