PMID- 24350817
OWN - NLM
STAT- MEDLINE
DCOM- 20150206
LR  - 20140516
IS  - 1563-5244 (Electronic)
IS  - 0883-0185 (Linking)
VI  - 33
IP  - 3
DP  - 2014 May-Jun
TI  - Molecular deciphering of the ABO system as a basis for novel diagnostics and 
      therapeutics in ABO incompatible transplantation.
PG  - 174-94
LID - 10.3109/08830185.2013.857408 [doi]
AB  - In recent years ABO incompatible kidney transplantation (KTx) has become a more 
      or less clinical routine procedure with graft and patient survival similar to 
      those of ABO compatible transplants. Antigen-specific immunoadsorption (IA) for 
      anti-A and anti-B antibody removal constitutes in many centers an important part 
      of the treatment protocol. ABO antibody titration by hemagglutination is guiding 
      the treatment; both if the recipient can be transplanted as well as in cases of 
      suspected rejections if antibody removal should be performed. Despite the overall 
      success of ABO incompatible KTx, there is still room for improvements and an 
      extension of the technology to include other solid organs. Based on an increased 
      understanding of the structural complexity and tissue distribution of ABH 
      antigens and the fine epitope specificity of the ABO antibody repertoire, 
      improved IA matrices and ABO antibody diagnostics should be developed. 
      Furthermore, understanding the molecular mechanisms behind accommodation of ABO 
      incompatible renal allografts could make it possible to induce long-term 
      allograft acceptance also in human leukocyte antigen (HLA) sensitized recipients 
      and, perhaps, also make clinical xenotransplantation possible.
FAU - Holgersson, Jan
AU  - Holgersson J
AD  - 1Department of Clinical Chemistry and Transfusion Medicine and.
FAU - Rydberg, Lennart
AU  - Rydberg L
FAU - Breimer, Michael E
AU  - Breimer ME
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131218
PL  - England
TA  - Int Rev Immunol
JT  - International reviews of immunology
JID - 8712260
RN  - 0 (ABO Blood-Group System)
SB  - IM
MH  - ABO Blood-Group System/*immunology
MH  - Blood Group Incompatibility/diagnosis/*immunology/therapy
MH  - Desensitization, Immunologic/methods/trends
MH  - Graft Rejection/etiology/*immunology/therapy
MH  - Graft Survival/immunology
MH  - Humans
MH  - Organ Transplantation/adverse effects/*methods
OTO - NOTNLM
OT  - ABO blood group system
OT  - blood group ABH antigens
OT  - blood group ABO antibodies
OT  - carbohydrate antigens
OT  - glycoengineering
OT  - mucins
OT  - transplantation
EDAT- 2013/12/20 06:00
MHDA- 2015/02/07 06:00
CRDT- 2013/12/20 06:00
PHST- 2013/12/20 06:00 [entrez]
PHST- 2013/12/20 06:00 [pubmed]
PHST- 2015/02/07 06:00 [medline]
AID - 10.3109/08830185.2013.857408 [doi]
PST - ppublish
SO  - Int Rev Immunol. 2014 May-Jun;33(3):174-94. doi: 10.3109/08830185.2013.857408. 
      Epub 2013 Dec 18.