PMID- 24351201
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131220
LR  - 20131219
IS  - 0964-7058 (Print)
IS  - 0964-7058 (Linking)
VI  - 3
IP  - 1
DP  - 1994 Mar
TI  - The relationship between high maternal aluminum ingestion and anemia-related 
      hematologic changes in rats.
PG  - 9-13
AB  - Microcytic, hypochromic anemia in dialysis patients has been associated with 
      aluminum toxicity. Since pregnant women and infants are high-risk groups for 
      iron-deficiency anemia, the purpose of this study was to investigate if high 
      maternal aluminum intake could cause anemia in dams and pups of rats. Eighteen 
      Sprague-Dawley (SD) female weanling rats were arranged in three groups under 
      randomized completely block design (RCBD) experiment design. Control, Low-Al and 
      High-Al groups had 0, 500, 2000 mg Al/kg diet added in the basal diet, 
      respectively, through growing, pregnancy and lactation. Rats were sacrificed 
      after weanling. Results indicated that either body weight gain or feed efficiency 
      was the lowest in High-Al groups dams (P<0.05). The body weights were the same in 
      neonates from mothers with various aluminum intakes. However, the higher the 
      maternal aluminum intakes, the lower the average body weight of weanling pups 
      (P<0.05). There was a positive correlation between Al intake and serum Al 
      concentration, Al intake and milk Al content of dams (r = 0.93 and r = 0.89, 
      respectively; P<0.05). Average milk and serum aluminum concentrations of dams 
      with high aluminum intake were higher than those in the Control and Low-Al 
      groups. Nevertheless, serum aluminum concentration in pups was not different 
      among the three groups. There was no difference in hematocrit (Hct), hemoglobin 
      (Hb) mean corpuscular hemoglobin concentration (MCHC), total iron binding 
      capacity, or transferrin saturation among dams. On the other hand, the pups in 
      the High-Al group had the highest Hct and Hb per unit body weight compared with 
      the other groups, probably due to smaller litter size.
FAU - Hsu, G S
AU  - Hsu GS
AD  - Graduate Institute of Nutrition and Food Sciences, Fu-Jen University, Taipei, 
      Taiwan, ROC.
FAU - Hsu, C Y
AU  - Hsu CY
LA  - eng
PT  - Journal Article
PL  - China
TA  - Asia Pac J Clin Nutr
JT  - Asia Pacific journal of clinical nutrition
JID - 9440304
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 2013/12/20 06:00
PHST- 2013/12/20 06:00 [entrez]
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PST - ppublish
SO  - Asia Pac J Clin Nutr. 1994 Mar;3(1):9-13.