PMID- 24352754 OWN - NLM STAT- MEDLINE DCOM- 20150924 LR - 20211021 IS - 1434-9949 (Electronic) IS - 0770-3198 (Linking) VI - 34 IP - 2 DP - 2015 Feb TI - Kimura's disease or IgG4-related disease? A case-based review. PG - 385-9 LID - 10.1007/s10067-013-2462-5 [doi] AB - Kimura's disease usually presents with benign painless soft tissue swelling around the head and neck areas with eosinophilia and high immunoglobulin E (IgE) levels. IgG4-related disease is characterized by fibrosis and sclerosis of the involved organs, with infiltration of IgG4-positive plasma cells. There are some similar clinical manifestations of these two diseases, with eosinophilia or high IgE levels often found in patients with IgG4-related disease. However, the relation between these two diseases is not well known. We report a 23-year-old man who had multiple neck lumps for longer than 1 year. He had remarkable eosinophilia and elevated serum IgE levels. Biopsy of his lymph nodes suggested the diagnosis of both Kimura's disease and IgG4-related disease. In this article, we discuss the relationship between Kimura's disease and IgG4-related disease. We also suggest a possible model ("allergen-specific immunotherapy") to illustrate our view that an increase in IgG4-positive plasma cells is an epiphenomenon of Kimura's disease. FAU - Liu, Lei AU - Liu L AD - Department of Rheumatology, Ningbo No. 2 Hospital, #41 Xibei Road, Ningbo, 315010, Zhejiang Province, China. FAU - Chen, Yong AU - Chen Y FAU - Fang, Zhi AU - Fang Z FAU - Kong, Jingping AU - Kong J FAU - Wu, Xiudi AU - Wu X FAU - Zhang, Zhen AU - Zhang Z LA - eng PT - Case Reports PT - Journal Article DEP - 20131219 PL - Germany TA - Clin Rheumatol JT - Clinical rheumatology JID - 8211469 RN - 0 (Immunoglobulin G) SB - IM MH - Angiolymphoid Hyperplasia with Eosinophilia/*diagnosis MH - Autoimmune Diseases/*diagnosis MH - Diagnosis, Differential MH - Humans MH - *Immunoglobulin G MH - Male MH - Young Adult EDAT- 2013/12/20 06:00 MHDA- 2015/09/25 06:00 CRDT- 2013/12/20 06:00 PHST- 2013/12/07 00:00 [received] PHST- 2013/12/08 00:00 [accepted] PHST- 2013/12/20 06:00 [entrez] PHST- 2013/12/20 06:00 [pubmed] PHST- 2015/09/25 06:00 [medline] AID - 10.1007/s10067-013-2462-5 [doi] PST - ppublish SO - Clin Rheumatol. 2015 Feb;34(2):385-9. doi: 10.1007/s10067-013-2462-5. Epub 2013 Dec 19.