PMID- 24353714
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131219
LR  - 20211021
IS  - 1682-024X (Print)
IS  - 1681-715X (Electronic)
IS  - 1681-715X (Linking)
VI  - 29
IP  - 5
DP  - 2013 Sep
TI  - Human papillomavirus infection a favorable prognostic factor in laryngeal 
      squamous cell carcinoma is associated with the expression of proliferating cell 
      nuclear antigen.
PG  - 1173-7
AB  - OBJECTIVE: It has been documented that human papilloma virus (HPV) DNA 
      replication requires proliferating cell nuclear antigen (PCNA). However the 
      association between them in tumors is still controversial. Up to now, the role of 
      HPV in laryngeal squamous cell carcinoma (LSCC) has not been clearly established, 
      and the correlation between HPV and PCNA in LSCC remains poorly explored. 
      METHODS: We retrospectively reviewed the clinicopathological features and 
      follow-up data of 71 patients with LSCC. The lesions were examined for PCNA using 
      immunohistochemistry, and for HPV using in situ hybridization. RESULTS: 31 
      (43.7%) cases showed infection of HPV and 38 (53.5%) showed overexpression of 
      PCNA. No significant difference of HPV status in clinicopathological features was 
      found. While there was a significant difference of PCNA expression in histology 
      grade but no significant difference of PCNA expression in other 
      clinicopathological features could be detected, and the expression of PCNA is not 
      a significant predictor of survival in LSCC patients. However, HPV infection is a 
      favorable prognostic factor in LSCC patients. Moreover, HPV infection is 
      associated with PCNA overexpression. CONCLUSION: Human papilloma virus (HPV) 
      infection is an indicator of better prognosis in LSCC and associated with the 
      expression of PCNA.
FAU - Jiang, Hua
AU  - Jiang H
FAU - Lin, Peng-Fang
AU  - Lin PF
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - Pak J Med Sci
JT  - Pakistan journal of medical sciences
JID - 100913117
PMC - PMC3858942
OTO - NOTNLM
OT  - Human papillomavirus
OT  - Laryngeal squamous cell carcinoma
OT  - Prognosis
OT  - Proliferating cell nuclear antigen
EDAT- 2013/12/20 06:00
MHDA- 2013/12/20 06:01
PMCR- 2013/09/01
CRDT- 2013/12/20 06:00
PHST- 2013/03/11 00:00 [received]
PHST- 2013/07/13 00:00 [accepted]
PHST- 2013/12/20 06:00 [entrez]
PHST- 2013/12/20 06:00 [pubmed]
PHST- 2013/12/20 06:01 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - pjms-29-1173 [pii]
AID - 10.12669/pjms.295.3606 [doi]
PST - ppublish
SO  - Pak J Med Sci. 2013 Sep;29(5):1173-7. doi: 10.12669/pjms.295.3606.