PMID- 24353833
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131219
LR  - 20240109
IS  - 1976-1457 (Print)
IS  - 2005-6168 (Electronic)
IS  - 1976-1457 (Linking)
VI  - 7
IP  - 6
DP  - 2013 Dec
TI  - Antioxidant effects of fucoxanthin rich powder in rats fed with high fat diet.
PG  - 475-80
LID - 10.4162/nrp.2013.7.6.475 [doi]
AB  - The purpose of this study was to determine the antioxidant effect of fucoxanthin. 
      After rats were fed a normal fat diet (NF), high fat diet (HF), and high fat with 
      0.2% fucoxanthin diet (HF + Fxn) for 4 weeks, the markers of oxidative stress and 
      antioxidant capacity like lipid peroxidation, plasma total antioxidant capacity 
      (TAC), and activities of antioxidant enzymes (catalase, superoxide dismutase 
      (SOD), and gluthathione peroxidase (GSH-Px)) were determined. mRNA expression of 
      transcription factor, nuclear erythroid factor like 2 (Nrf2), and its target 
      genes such as NAD(P)H quinone oxidoreductase1 (NQO1) and heme oxygenase-1 (HO-1) 
      were also determined. Mean weight gain in the HF + Fxn group was lower, without 
      statistical significance, and the total food intake in the HF + Fxn group was 
      lower than that in the HF group (P < 0.05). The activity of GSH-Px (P < 0.05) in 
      plasma was significantly higher in the HF + Fxn group than those in the HF group 
      (P < 0.05). In the liver, the activities of catalase (P < 0.05) and GSH-Px (P < 
      0.05) in the HF + Fxn group were significantly higher than those in the HF group. 
      Plasma TAC level was significantly higher in the HF + Fxn group than that in the 
      HF group (P < 0.05). Lipid peroxidation in plasma tended to be lower without 
      statistical significance. Fucoxanthin supplements were shown to have higher mRNA 
      expression of Nrf2 and NQO1 than those in the high fat diet only group (P < 
      0.05). In conclusion, supplementation of fucoxanthin improved the antioxidant 
      capacity, depleted by high fat diet, by activating the Nrf2 pathway and its 
      downstream target gene NQO1. Therefore, supplementation of fucoxanthin, 
      especially for those who consume high fat in their diet, may benefit from reduced 
      risk of oxidative stress.
FAU - Ha, Ae Wha
AU  - Ha AW
AD  - Department of Food Science and Nutrition, Dankook University, 126 Jukjeon-dong, 
      Suji-gu, Yongin, Gyunggi 448-701, Korea.
FAU - Na, Se Jung
AU  - Na SJ
AD  - Department of Food Science and Nutrition, Dankook University, 126 Jukjeon-dong, 
      Suji-gu, Yongin, Gyunggi 448-701, Korea.
FAU - Kim, Woo Kyoung
AU  - Kim WK
AD  - Department of Food Science and Nutrition, Dankook University, 126 Jukjeon-dong, 
      Suji-gu, Yongin, Gyunggi 448-701, Korea.
LA  - eng
PT  - Journal Article
DEP - 20131129
PL  - Korea (South)
TA  - Nutr Res Pract
JT  - Nutrition research and practice
JID - 101311052
PMC - PMC3865270
OTO - NOTNLM
OT  - Fucoxanthin
OT  - Nrf2
OT  - antioxidant
OT  - high fat diet
OT  - oxidative stress
EDAT- 2013/12/20 06:00
MHDA- 2013/12/20 06:01
PMCR- 2013/12/01
CRDT- 2013/12/20 06:00
PHST- 2013/06/17 00:00 [received]
PHST- 2013/10/19 00:00 [revised]
PHST- 2013/10/23 00:00 [accepted]
PHST- 2013/12/20 06:00 [entrez]
PHST- 2013/12/20 06:00 [pubmed]
PHST- 2013/12/20 06:01 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - 10.4162/nrp.2013.7.6.475 [doi]
PST - ppublish
SO  - Nutr Res Pract. 2013 Dec;7(6):475-80. doi: 10.4162/nrp.2013.7.6.475. Epub 2013 
      Nov 29.