PMID- 24354924
OWN - NLM
STAT- MEDLINE
DCOM- 20141107
LR  - 20211129
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 39
IP  - 6
DP  - 2014 Mar
TI  - Knockdown of tropomyosin-related kinase B receptor expression in the nucleus 
      accumbens shell prevents intermittent social defeat stress-induced 
      cross-sensitization to amphetamine in rats.
PG  - 1009-1017
LID - 10.1111/ejn.12464 [doi]
AB  - The nucleus accumbens (NAc) is a critical brain region for the rewarding effects 
      of drugs of abuse. Brain-derived neurotrophic factor (BDNF) can facilitate 
      stress- and drug-induced neuroadaptation in the mesocorticolimbic system. 
      BDNF-containing projections to the NAc originate from the ventral tegmental area 
      (VTA) and the prefrontal cortex, and BDNF release activates tropomyosin-related 
      kinase B (TrkB). In this study, we examined the necessity for BDNF-TrkB signaling 
      in the NAc shell during social defeat stress-induced cross-sensitization to 
      amphetamine. Adeno-associated virus expressing short hairpin RNA directed against 
      TrkB (AAV-shTrkB) was infused bilaterally into the NAc shell to knock down TrkB, 
      whereas AAV-GFP (green fluorescent protein) was used as the control virus. Rats 
      were exposed to intermittent social defeat stress or handling procedures; 
      amphetamine challenge was given at 10 days after the last defeat and locomotor 
      activity was measured. Stressed rats that received the control virus showed 
      cross-sensitization to amphetamine compared with the handled rats. In contrast, 
      NAc TrkB knockdown prevented social defeat stress-induced cross-sensitization. 
      TrkB knockdown in the NAc was found to reduce the level of phospho-extracellular 
      signal-regulated kinase 1 in this region. NAc TrkB knockdown also prevented 
      stress-induced elevation of BDNF and the glutamate receptor type 1 (GluA1) 
      subunit of AMPA receptor in the VTA, as well as DeltaFosB expression in the NAc. 
      These findings indicated that BDNF-TrkB signaling in the NAc shell was required 
      for social defeat stress-induced cross-sensitization. NAc TrkB-BDNF signaling 
      also appeared to be involved in the regulation of GluA1 in the VTA, as well as in 
      the NAc DeltaFosB accumulation that could trigger cross-sensitization after social 
      defeat stress.
CI  - (c) 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Wang, Junshi
AU  - Wang J
AD  - Neuroscience Program, Arizona State University, Tempe, AZ, USA.
FAU - Bina, Robert W
AU  - Bina RW
AD  - Department of Basic Medical Sciences, University of Arizona, College of Medicine, 
      425 N 5th Street, Phoenix, AZ, 85004, USA.
FAU - Wingard, Jeffrey C
AU  - Wingard JC
AD  - Beth Israel Deaconess Medical Center, Boston, MA, USA.
FAU - Terwilliger, Ernest F
AU  - Terwilliger EF
AD  - Beth Israel Deaconess Medical Center, Boston, MA, USA.
FAU - Hammer, Ronald P Jr
AU  - Hammer RP Jr
AD  - Neuroscience Program, Arizona State University, Tempe, AZ, USA.
AD  - Department of Basic Medical Sciences, University of Arizona, College of Medicine, 
      425 N 5th Street, Phoenix, AZ, 85004, USA.
AD  - Departments of Pharmacology and Psychiatry, University of Arizona, College of 
      Medicine, Phoenix, AZ, USA.
FAU - Nikulina, Ella M
AU  - Nikulina EM
AD  - Department of Basic Medical Sciences, University of Arizona, College of Medicine, 
      425 N 5th Street, Phoenix, AZ, 85004, USA.
LA  - eng
GR  - R01 DA026451/DA/NIDA NIH HHS/United States
GR  - DA026451/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131219
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fosb protein, rat)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, AMPA)
RN  - CK833KGX7E (Amphetamine)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - TFZ3H25BS1 (glutamate receptor ionotropic, AMPA 1)
SB  - IM
MH  - Amphetamine/*pharmacology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - *Central Nervous System Sensitization
MH  - Locomotion
MH  - Male
MH  - Nucleus Accumbens/drug effects/*metabolism/physiology
MH  - Proto-Oncogene Proteins c-fos/genetics/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/genetics/*metabolism
MH  - Receptors, AMPA/genetics/metabolism
MH  - Social Behavior
MH  - Stress, Psychological/*metabolism/physiopathology
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - cross-sensitization
OT  - nucleus accumbens
OT  - social stress
OT  - tropomyosin-related kinase B
OT  - ventral tegmental area
EDAT- 2013/12/21 06:00
MHDA- 2014/11/08 06:00
CRDT- 2013/12/21 06:00
PHST- 2013/08/15 00:00 [received]
PHST- 2013/10/20 00:00 [revised]
PHST- 2013/11/26 00:00 [accepted]
PHST- 2013/12/21 06:00 [entrez]
PHST- 2013/12/21 06:00 [pubmed]
PHST- 2014/11/08 06:00 [medline]
AID - 10.1111/ejn.12464 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2014 Mar;39(6):1009-1017. doi: 10.1111/ejn.12464. Epub 2013 Dec 
      19.