PMID- 24355005
OWN - NLM
STAT- MEDLINE
DCOM- 20140829
LR  - 20131220
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 83
IP  - 1
DP  - 2014 Jan
TI  - HLA frequencies and associations in cystic fibrosis.
PG  - 27-31
LID - 10.1111/tan.12265 [doi]
AB  - Cystic fibrosis (CF) is classically attributed to the dysfunction of the single 
      CF transmembrane conductance regulator gene. The incidence of human leukocyte 
      antigen (HLA) polymorphisms in different CF-associated diseases raises the 
      question of an unequal distribution of HLA genotypes in CF. This study aimed to 
      evaluate HLA gene frequencies and possible associations in CF patients compared 
      with a control population. Frequencies of HLA-DRB1, HLA-DQA1 and HLA-DQB1, 
      performed by intermediate resolution typing using Luminex sequence-specific 
      oligonucleotide, and epitope counts were similar in 340 CF patients when compared 
      with 400 control subjects. In conclusion, HLA-DRB1, -DQA1 and -DQB1 do not seem 
      to influence susceptibility to CF. Whether HLA plays a role in the severity of CF 
      disease needs to be investigated.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Adriaanse, M P M
AU  - Adriaanse MP
AD  - Department of Paediatrics & Nutrition and Toxicology Research Institute 
      Maastricht (NUTRIM), Maastricht University Medical Centre, Maastricht, the 
      Netherlands.
FAU - Vreugdenhil, A C E
AU  - Vreugdenhil AC
FAU - Groeneweg, M
AU  - Groeneweg M
FAU - Bruggenwirth, H T
AU  - Bruggenwirth HT
FAU - Castelijns, S J A M
AU  - Castelijns SJ
FAU - van der Ent, C K
AU  - van der Ent CK
FAU - Voorter, C E M
AU  - Voorter CE
FAU - Tilanus, M G J
AU  - Tilanus MG
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator)
SB  - IM
MH  - Cystic Fibrosis/*genetics/*immunology
MH  - Cystic Fibrosis Transmembrane Conductance Regulator/genetics
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/genetics/*immunology
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic
OTO - NOTNLM
OT  - HLA antigens
OT  - HLA-DQ alpha-chains
OT  - HLA-DQ beta-chains
OT  - HLA-DRB1 chains
OT  - cystic fibrosis
OT  - cystic fibrosis transmembrane conductance regulator
EDAT- 2013/12/21 06:00
MHDA- 2014/08/30 06:00
CRDT- 2013/12/21 06:00
PHST- 2013/07/18 00:00 [received]
PHST- 2013/10/30 00:00 [revised]
PHST- 2013/11/14 00:00 [accepted]
PHST- 2013/12/21 06:00 [entrez]
PHST- 2013/12/21 06:00 [pubmed]
PHST- 2014/08/30 06:00 [medline]
AID - 10.1111/tan.12265 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Jan;83(1):27-31. doi: 10.1111/tan.12265.