PMID- 24355224
OWN - NLM
STAT- MEDLINE
DCOM- 20140423
LR  - 20231213
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 26
IP  - 4
DP  - 2013 Oct-Dec
TI  - Differential expression of immune-modulatory molecule HLA-E in non-neoplastic and 
      neoplastic lesions of the thyroid.
PG  - 889-96
AB  - Human leukocyte antigen (HLA)–E is a non-classical molecule of the 
      histocompatibility complex that functions as one of the main ligands of the 
      Natural Killer (NK) cell inhibitory receptor CD94/NKG2A and inhibits its potent 
      cytotoxic activity. Due to the important role of NK cells in combating neoplasm, 
      we hypothesized that the differential expression of HLA-E could favor the 
      progression of heterogeneous thyroid tumors.Using an immunohistochemistry 
      technique in 143 biopsies of thyroid tumors, including benign and malignant 
      neoplasms and goiters, we evaluated the expression of HLA-E among various tumor 
      types and its association with the clinicopathological factors of diseases. We 
      verified high HLA-E expression in all types of neoplastic tumors, although no 
      significant differences between the groups were found. Low expression was 
      observed in 95 percent of the goiter samples, showing significant differences 
      between neoplastic and non-neoplastic lesions. Furthermore, a significant result 
      was found with regard to the tumor size, with high HLA-E expression being related 
      to smaller tumors. Therefore, our data suggest that an increase in HLA-E may be 
      associated with the establishment of thyroid neoplasms, with either benign or 
      malignant features.
FAU - Zanetti, B R
AU  - Zanetti BR
AD  - Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, 
      Brazil.
FAU - Carvalho-Galano, D F
AU  - Carvalho-Galano DF
AD  - Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, 
      Brazil.
FAU - Feitosa, N L F
AU  - Feitosa NL
AD  - Department of Internal Medicine, Division of Endocrinology and Metabolism, 
      Ribeirao Preto Medical School, University of Sao Paulo, Brazil.
FAU - Hassumi-Fukasawa, M K
AU  - Hassumi-Fukasawa MK
AD  - Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, 
      Brazil.
FAU - Miranda-Camargo, F A
AU  - Miranda-Camargo FA
AD  - Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, 
      Brazil.
FAU - Maciel, L M Z
AU  - Maciel LM
AD  - Department of Internal Medicine, Division of Endocrinology and Metabolism, 
      Ribeirao Preto Medical School, University of Sao Paulo, Brazil.
FAU - Ribeiro-Silva, A
AU  - Ribeiro-Silva A
AD  - Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, 
      Brazil.
FAU - Soares, E G
AU  - Soares EG
AD  - Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, 
      Brazil.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Histocompatibility Antigens Class I/*analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Thyroid Gland/*immunology
MH  - Thyroid Neoplasms/*immunology
MH  - HLA-E Antigens
EDAT- 2013/12/21 06:00
MHDA- 2014/04/24 06:00
CRDT- 2013/12/21 06:00
PHST- 2013/12/21 06:00 [entrez]
PHST- 2013/12/21 06:00 [pubmed]
PHST- 2014/04/24 06:00 [medline]
AID - 7 [pii]
AID - 10.1177/039463201302600407 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2013 Oct-Dec;26(4):889-96. doi: 
      10.1177/039463201302600407.