PMID- 24355486
OWN - NLM
STAT- MEDLINE
DCOM- 20141010
LR  - 20220331
IS  - 1096-3618 (Electronic)
IS  - 1044-5323 (Linking)
VI  - 25
IP  - 6
DP  - 2013 Dec 15
TI  - Biology of IL-36 cytokines and their role in disease.
PG  - 458-65
LID - S1044-5323(13)00155-3 [pii]
LID - 10.1016/j.smim.2013.11.003 [doi]
AB  - IL-36alpha, IL-36beta, IL-36gamma, and IL-36Ra, collectively called IL-36 cytokines, are 
      part of the IL-1 family. IL-36alpha, IL-36beta, and IL-36gamma are IL-36 receptor (IL-36R) 
      agonists, while IL-36Ra is a receptor antagonist that blocks the activation of 
      IL-36R signaling. IL-36 cytokines require processing in order to become fully 
      active, however the protease(s) responsible for this are currently not known. The 
      IL-36 receptor pathway activates dendritic cells and plays a role in polarizing 
      T-helper responses. The skin is the predominant site where IL-36 cytokines are 
      expressed and several reports have established that they play a significant role 
      in the pathogenesis of skin diseases. In this review the discovery and biological 
      function of the cytokines IL-36alpha, IL-36beta, IL-36gamma and IL-36Ra will be discussed, 
      and their role in the pathogenesis of a wide variety of diseases.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Gresnigt, Mark S
AU  - Gresnigt MS
AD  - Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The 
      Netherlands; Nijmegen Institute for Infection, Inflammation, and Immunity (N4i), 
      The Netherlands.
FAU - van de Veerdonk, Frank L
AU  - van de Veerdonk FL
AD  - Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The 
      Netherlands; Nijmegen Institute for Infection, Inflammation, and Immunity (N4i), 
      The Netherlands; Department of Medicine, University of Colorado Denver, Aurora, 
      CO, USA. Electronic address: Frank.vandeVeerdonk@radboudumc.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131217
PL  - England
TA  - Semin Immunol
JT  - Seminars in immunology
JID - 9009458
RN  - 0 (IL36A protein, human)
RN  - 0 (IL36B protein, human)
RN  - 0 (IL36G protein, human)
RN  - 0 (IL36RN protein, human)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukins)
RN  - 0 (Receptors, Interleukin)
SB  - IM
MH  - Dendritic Cells/immunology
MH  - Humans
MH  - Interleukin-1/*immunology
MH  - Interleukins/biosynthesis/genetics/*metabolism
MH  - Receptors, Interleukin/agonists/antagonists & inhibitors/*immunology
MH  - Signal Transduction
MH  - Skin/immunology
MH  - T-Lymphocytes, Helper-Inducer/immunology
OTO - NOTNLM
OT  - IL-1 family
OT  - Interleukin-36
OT  - Pathogenesis
OT  - Skin inflammation
EDAT- 2013/12/21 06:00
MHDA- 2014/10/11 06:00
CRDT- 2013/12/21 06:00
PHST- 2013/12/21 06:00 [entrez]
PHST- 2013/12/21 06:00 [pubmed]
PHST- 2014/10/11 06:00 [medline]
AID - S1044-5323(13)00155-3 [pii]
AID - 10.1016/j.smim.2013.11.003 [doi]
PST - ppublish
SO  - Semin Immunol. 2013 Dec 15;25(6):458-65. doi: 10.1016/j.smim.2013.11.003. Epub 
      2013 Dec 17.