PMID- 24355528 OWN - NLM STAT- MEDLINE DCOM- 20140829 LR - 20160526 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 152 IP - 1 DP - 2014 Jan TI - Health-related quality of life and metabolic risk in patients with psychosis. PG - 295-9 LID - S0920-9964(13)00643-9 [pii] LID - 10.1016/j.schres.2013.11.029 [doi] AB - Improved Health-related quality of life (HRQoL) is an alternative treatment goal for individuals with psychosis, who have up to two times greater prevalence of type 2 diabetes, hypertension and obesity than the general population. AIM: to compare HRQoL in patients with psychosis, especially schizophrenia, with a reference sample and explore the relationship between HRQoL and metabolic risk factors in these patients. METHODS: a prospective cohort study was carried out in specialized psychiatric outpatient departments in Sweden. The patients were invited consecutively. A prospective population-based study of public health in the south-east of Sweden served as reference group. Patients were assessed with psychiatric questionnaires that included Global Assessment of Functioning (GAF). Health-related quality of life was assessed using the questionnaire EQ5D, both for patients and the population, and several other health status outcomes were used. RESULTS: At 73%, schizophrenia and schizoaffective disorder were the most common diagnoses in the patient group. The results in patients (n=903) and population (n=7238) showed significant differences in lower EQ5D among patients. According to the definition by the International Diabetes Federation (IDF), elevated blood pressure was the only metabolic risk associated with lower HRQoL in patients. Raised LDL-cholesterol levels were also significantly related to lower HRQoL. CONCLUSION: patients suffering from psychosis had significantly lower HRQoL regarding all components in EQ5D, except for the pain/discomfort component. Almost half of the patient group met the criteria for metabolic syndrome. According to the IDF criteria, elevated blood pressure was the only metabolic risk factor that had an impact on HRQoL. CI - Copyright (c) 2013 Elsevier B.V. All rights reserved. FAU - Foldemo, Anniqa AU - Foldemo A AD - Department of Medical and Health Sciences, Linkoping University, Sweden; R&D Department, County Council of Ostergotland, Linkoping, Sweden. Electronic address: anniqa.foldemo@liu.se. FAU - Wardig, Rikard AU - Wardig R AD - Department of Medical and Health Sciences, Linkoping University, Sweden. FAU - Bachrach-Lindstrom, Margareta AU - Bachrach-Lindstrom M AD - Department of Medical and Health Sciences, Linkoping University, Sweden. FAU - Edman, Gunnar AU - Edman G AD - Department of Molecular Medicine and Surgery, Neurogenetics, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. FAU - Holmberg, Tommy AU - Holmberg T AD - Department of Psychiatry, Tiohundra AB, Norrtalje, Sweden. FAU - Lindstrom, Torbjorn AU - Lindstrom T AD - Department of Medical and Health Sciences, Linkoping University, Sweden; Department of Endocrinology, County Council of Ostergotland, Linkoping, Sweden. FAU - Valter, Lars AU - Valter L AD - Department of Psychiatry, Tiohundra AB, Norrtalje, Sweden. FAU - Osby, Urban AU - Osby U AD - Department of Molecular Medicine and Surgery, Neurogenetics, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, Tiohundra AB, Norrtalje, Sweden. LA - eng PT - Journal Article DEP - 20131217 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Analysis of Variance MH - Female MH - Humans MH - Logistic Models MH - Male MH - Metabolic Diseases/*epidemiology MH - Middle Aged MH - Psychotic Disorders/*epidemiology/*psychology MH - Quality of Life/*psychology MH - Retrospective Studies MH - Risk Factors MH - Sweden/epidemiology MH - Young Adult OTO - NOTNLM OT - Health-related quality of life OT - Metabolic syndrome OT - Reference group OT - Schizophrenia EDAT- 2013/12/21 06:00 MHDA- 2014/08/30 06:00 CRDT- 2013/12/21 06:00 PHST- 2013/04/16 00:00 [received] PHST- 2013/11/12 00:00 [revised] PHST- 2013/11/16 00:00 [accepted] PHST- 2013/12/21 06:00 [entrez] PHST- 2013/12/21 06:00 [pubmed] PHST- 2014/08/30 06:00 [medline] AID - S0920-9964(13)00643-9 [pii] AID - 10.1016/j.schres.2013.11.029 [doi] PST - ppublish SO - Schizophr Res. 2014 Jan;152(1):295-9. doi: 10.1016/j.schres.2013.11.029. Epub 2013 Dec 17.