PMID- 24357032
OWN - NLM
STAT- MEDLINE
DCOM- 20140606
LR  - 20181202
IS  - 1552-8618 (Electronic)
IS  - 0730-7268 (Linking)
VI  - 33
IP  - 1
DP  - 2014 Jan
TI  - Age-related polychlorinated biphenyl dynamics in immature bull sharks 
      (Carcharhinus leucas).
PG  - 35-43
LID - 10.1002/etc.2402 [doi]
AB  - Polychlorinated biphenyls (PCBs) were quantified in liver tissues of bull sharks 
      (Carcharhinus leucas) ranging in age from <4 wk to >3 yr. Summed values of PCBs 
      (SigmaPCBs) ranged from 310 ng/g to 22 070 ng/g (lipid wt) across age classes with 
      SigmaPCB concentrations for the youngest sharks in the present study (<4 wk; 
      5230 +/- 2170 ng/g lipid wt) determined to not significantly differ from those 
      quantified in >3-yr-old sharks, highlighting the extent of exposure of this young 
      life stage to this class of persistent organic pollutants (POPs). Age 
      normalization of PCB congener concentrations to those measured for the youngest 
      sharks demonstrated a significant hydrophobicity (log octanol/water partition 
      coefficient [KOW ]) effect that was indicative of maternal offloading of highly 
      hydrophobic (log KOW >/=6.5) congeners to the youngest individuals. A distinct 
      shift in the PCB congener profiles was also observed as these young sharks grew 
      in size. This shift was consistent with a transition from the maternally 
      offloaded signal to the initiation of exogenous feeding and the contributions of 
      mechanisms including growth dilution and whole-body elimination. These results 
      add to the growing pool of literature documenting substantially high 
      concentrations of POPs in juvenile sharks that are most likely attributable to 
      maternal offloading. Collectively, such results underscore the potential 
      vulnerability of young sharks to POP exposure and pose additional concerns for 
      shark-conservation efforts.
CI  - (c) 2013 SETAC.
FAU - Olin, Jill A
AU  - Olin JA
AD  - Great Lakes Institute for Environmental Research, University of Windsor, Windsor, 
      Ontario, Canada.
FAU - Beaudry, Marina
AU  - Beaudry M
FAU - Fisk, Aaron T
AU  - Fisk AT
FAU - Paterson, Gordon
AU  - Paterson G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131113
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (Water Pollutants, Chemical)
RN  - 059QF0KO0R (Water)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - NV1779205D (1-Octanol)
SB  - IM
MH  - 1-Octanol/chemistry
MH  - Aging/*physiology
MH  - Animals
MH  - Environmental Monitoring
MH  - Female
MH  - Florida
MH  - Liver/metabolism
MH  - Male
MH  - Polychlorinated Biphenyls/chemistry/*metabolism
MH  - Sharks/*metabolism
MH  - Water/chemistry
MH  - Water Pollutants, Chemical/chemistry/*metabolism
OTO - NOTNLM
OT  - Hydrophobicity
OT  - Maternal transfer
OT  - Shark liver
OT  - Umbilical scar stage
OT  - Young-of-year
EDAT- 2013/12/21 06:00
MHDA- 2014/06/07 06:00
CRDT- 2013/12/21 06:00
PHST- 2013/03/25 00:00 [received]
PHST- 2013/07/29 00:00 [revised]
PHST- 2013/09/18 00:00 [accepted]
PHST- 2013/12/21 06:00 [entrez]
PHST- 2013/12/21 06:00 [pubmed]
PHST- 2014/06/07 06:00 [medline]
AID - 10.1002/etc.2402 [doi]
PST - ppublish
SO  - Environ Toxicol Chem. 2014 Jan;33(1):35-43. doi: 10.1002/etc.2402. Epub 2013 Nov 
      13.