PMID- 24358040
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131220
LR  - 20220321
IS  - 1735-143X (Print)
IS  - 1735-3408 (Electronic)
IS  - 1735-143X (Linking)
VI  - 13
IP  - 12
DP  - 2013
TI  - Clinical Profile and HLA Typing of Autoimmune Hepatitis From Pakistan.
PG  - e13598
LID - 10.5812/hepatmon.13598 [doi]
LID - e13598
AB  - BACKGROUND: Human leukocyte antigen (HLA) typing in autoimmune hepatitis (AIH) 
      has been investigated in different populations and ethnic groups, but no such 
      data is available from Pakistan. OBJECTIVES: The aim of this study was to 
      evaluate the clinical profile of autoimmune hepatitis (AIH), and determine the 
      associated antigens and alleles by performing HLA typing. PATIENTS AND METHODS: A 
      total of 58 patients, diagnosed and treated as AIH in the last 10 years were 
      reviewed. Diagnosis was based on International AIH Group criteria. Forty one 
      patients underwent liver biopsy. HLA typing was performed in 44 patients and 912 
      controls by serological method for HLA A and B, and by PCR technique using 
      sequence specific primers for DR alleles. RESULTS: Of 58 cases, 35 were females 
      (60.3%). The median age was 14.5 (range 4-70 years), and AIH score was 14 
      (10-22). Thirty-six (62.0%) patients had type 1 AIH, 10 (17.2%) type 2, and the 
      remaining 12 were seronegative with biopsy proven AIH. Forty-nine patients 
      (84.4%) had cirrhosis. Twenty-four (41.4%) patients had ascites at the time of 
      presentation. Among 41 patients who underwent liver biopsy, thirty-two had 
      advance stages III and IV disease, and twenty had severe grade of inflammation. 
      Fifteen patients had other associated autoimmune diseases and one developed 
      hepatocellular carcinoma. HLA A2 (P = 0.036), HLA A9 (23) (P = 0.018), HLA A10 
      (25) (P = 0.000), HLA A19 (33) (P = 0.000), HLA B15 (63) (P = 0.007), HLA B40 
      (61) ( P = 0.002), HLA DR6 (P = 0.001) with its subtypes HLA-DRB1*13 (P = 0.032) 
      and HLA-DRB1*14 (p = 0.017) were more prevalent in AIH with statistical 
      significance than controls. CONCLUSIONS: AIH in our region presents with advanced 
      disease affecting predominantly children and adolescents. There is a genetic 
      association of HLA DR6 along with other alleles and antigens in our patients with 
      AIH.
FAU - Hassan, Nasir
AU  - Hassan N
AD  - Department of Hepatogastroenterology, Sindh Institute of Urology and 
      Transplantation, Karachi, Pakistan.
FAU - Siddiqui, Adeelur Rehman
AU  - Siddiqui AR
AD  - Department of Hepatogastroenterology, Sindh Institute of Urology and 
      Transplantation, Karachi, Pakistan.
FAU - Abbas, Zaigham
AU  - Abbas Z
AD  - Department of Hepatogastroenterology, Sindh Institute of Urology and 
      Transplantation, Karachi, Pakistan.
FAU - Hassan, Syed Mujahid
AU  - Hassan SM
AD  - Department of Hepatogastroenterology, Sindh Institute of Urology and 
      Transplantation, Karachi, Pakistan.
FAU - Soomro, Ghous Bux
AU  - Soomro GB
AD  - Department of Hepatogastroenterology, Sindh Institute of Urology and 
      Transplantation, Karachi, Pakistan.
FAU - Mubarak, Muhammed
AU  - Mubarak M
AD  - Department of Pathology, Sindh Institute of Urology and Transplantation, Karachi, 
      Pakistan.
FAU - Anis, Sabiha
AU  - Anis S
AD  - Molecular Diagnostics and Immunology, Sindh Institute of Urology and 
      Transplantation, Karachi, Pakistan.
FAU - Muzaffar, Rana
AU  - Muzaffar R
AD  - Molecular Diagnostics and Immunology, Sindh Institute of Urology and 
      Transplantation, Karachi, Pakistan.
FAU - Zafar, Mirza Naqi
AU  - Zafar MN
AD  - Department of Pathology, Sindh Institute of Urology and Transplantation, Karachi, 
      Pakistan.
LA  - eng
PT  - Journal Article
DEP - 20131216
PL  - Netherlands
TA  - Hepat Mon
JT  - Hepatitis monthly
JID - 101277874
PMC - PMC3867004
OTO - NOTNLM
OT  - Alleles, HLA-DR6 Antigen
OT  - Hepatitis, Autoimmune
OT  - Histocompatibility Testing
OT  - Pakistan
EDAT- 2013/12/21 06:00
MHDA- 2013/12/21 06:01
PMCR- 2013/12/16
CRDT- 2013/12/21 06:00
PHST- 2013/07/15 00:00 [received]
PHST- 2013/10/22 00:00 [revised]
PHST- 2013/11/16 00:00 [accepted]
PHST- 2013/12/21 06:00 [entrez]
PHST- 2013/12/21 06:00 [pubmed]
PHST- 2013/12/21 06:01 [medline]
PHST- 2013/12/16 00:00 [pmc-release]
AID - 10.5812/hepatmon.13598 [doi]
PST - epublish
SO  - Hepat Mon. 2013 Dec 16;13(12):e13598. doi: 10.5812/hepatmon.13598. eCollection 
      2013.