PMID- 24358796
OWN - NLM
STAT- MEDLINE
DCOM- 20140407
LR  - 20190221
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 27
IP  - 17
DP  - 2013 Sep
TI  - [The expression of ubiquitin in laryngeal squamous cell carcinoma with lymph node 
      metastasis and its clinical significance].
PG  - 944-7
AB  - OBJECTIVE: To investigate the ubiquitin expression in laryngeal squamous cell 
      carcinoma (LSCC) whether along with local lymph node metastasis, and further 
      study its correlation with local lymph node metastasis and other 
      clinicopathological parameters in laryngeal squamous cell carcinoma. METHOD: We 
      detected the different expression level of ubiquitin in paraffin specimens 
      between 19 cases of LSCC associated with cervical lymph node metastasis LSCC(N+) 
      and 20 cases of LSCC not associated with cervical lymph node metastasis LSCC(N-) 
      by immunohistochemical staining combined with stereology image analysis system. 
      Statistics were analyzed by student test, variance analysis and ROC curve. 
      RESULT: Ubiquitin expression in LSCC(N+) was significantly higher than LSCC(N-) 
      (P < 0.01); their expression level was not correlated with age,history of 
      tobacco, alcohol addiction, clinical stage and primary site,etc. CONCLUSION: 
      Ubiquitin was significantly up-expressed in LSCC(N+) than ILSCC (N-), which may 
      imply that it is one of the important elements in mechanism of lymph node 
      metastasis in LSCC.
FAU - Cai, Gengming
AU  - Cai G
AD  - Department of Otolaryngoloy, the First Hospital of Quanzhou, Fujian Medical 
      University, Quanzhou, 362000, China.
FAU - Zhu, Gangcai
AU  - Zhu G
AD  - Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central 
      South University.
FAU - Liu, Yong
AU  - Liu Y
AD  - Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central 
      South University.
FAU - Yu, Changyun
AU  - Yu C
AD  - Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central 
      South University.
FAU - Tan, Haolei
AU  - Tan H
AD  - Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central 
      South University.
FAU - Qiu, Yuanzheng
AU  - Qiu Y
AD  - Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central 
      South University.
FAU - Zhang, Xin
AU  - Zhang X
AD  - Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central 
      South University.
FAU - Huang, Donghai
AU  - Huang D
AD  - Department of Otolaryngoloy-Head and Neck Surgery, Xiangya Hospital, Central 
      South University.
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Ubiquitin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/pathology
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymph Nodes/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Ubiquitin/*metabolism
EDAT- 2013/12/24 06:00
MHDA- 2014/04/08 06:00
CRDT- 2013/12/24 06:00
PHST- 2013/12/24 06:00 [entrez]
PHST- 2013/12/24 06:00 [pubmed]
PHST- 2014/04/08 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Sep;27(17):944-7.