PMID- 2435883
OWN - NLM
STAT- MEDLINE
DCOM- 19870511
LR  - 20190912
IS  - 0386-846X (Print)
IS  - 0386-846X (Linking)
VI  - 9
IP  - 11
DP  - 1986 Nov
TI  - Effect of cinnarizine on IgE antibody mediated allergic reaction in mice and 
      rats.
PG  - 923-7
AB  - The effect of cinnarizine on immunoglobulin E (IgE) antibody mediated allergic 
      reactions in mice and rats was investigated. Nifedipine and tranilast were used 
      as comparative drugs. The dye leakage caused by IgE antibody mediated passive 
      cutaneous anaphylaxis (PCA) in mouse ear was clearly inhibited by cinnarizine 
      administered both orally and intraperitoneally. The inhibitory action of 
      cinnarizine for PCA was as potent as nifedipine and superior to tranilast. 
      Cinnarizine clearly inhibited the increase in capillary permeability caused by 
      histamine and calcium ionophore A 23187 (A 23187) but not by LTD4 in mouse ear. 
      Nifedipine inhibited the increases of capillary permeability caused by A 23187, 
      histamine and LTD4. Tranilast inhibited A 23187 induced vasculitis but not 
      histamine or LTD4-induced reaction. Cinnarizine had no significant effect on the 
      release of histamine caused by antigen or A 23187 from rat peritoneal mast cells. 
      Nifedipine and tranilast inhibited the release of histamine caused by both 
      antigen and A 23187 from rat peritoneal mast cells.
FAU - Nagai, H
AU  - Nagai H
FAU - Yakuo, I
AU  - Yakuo I
FAU - Yamada, H
AU  - Yamada H
FAU - Inagaki, N
AU  - Inagaki N
FAU - Goto, S
AU  - Goto S
FAU - Koda, A
AU  - Koda A
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Pharmacobiodyn
JT  - Journal of pharmacobio-dynamics
JID - 7901854
RN  - 0 (Histamine Antagonists)
RN  - 0 (SRS-A)
RN  - 0 (ortho-Aminobenzoates)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 37H9VM9WZL (Calcimycin)
RN  - 3DI2E1X18L (Cinnarizine)
RN  - HVF50SMY6E (tranilast)
RN  - I9ZF7L6G2L (Nifedipine)
SB  - IM
MH  - Animals
MH  - Calcimycin/antagonists & inhibitors
MH  - Capillary Permeability/drug effects
MH  - Cinnarizine/*pharmacology
MH  - Female
MH  - Histamine Antagonists
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E/*physiology
MH  - Male
MH  - Mast Cells/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nifedipine/pharmacology
MH  - Passive Cutaneous Anaphylaxis/*drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - SRS-A/antagonists & inhibitors
MH  - ortho-Aminobenzoates/pharmacology
EDAT- 1986/11/01 00:00
MHDA- 1986/11/01 00:01
CRDT- 1986/11/01 00:00
PHST- 1986/11/01 00:00 [pubmed]
PHST- 1986/11/01 00:01 [medline]
PHST- 1986/11/01 00:00 [entrez]
AID - 10.1248/bpb1978.9.923 [doi]
PST - ppublish
SO  - J Pharmacobiodyn. 1986 Nov;9(11):923-7. doi: 10.1248/bpb1978.9.923.