PMID- 24361004
OWN - NLM
STAT- MEDLINE
DCOM- 20140925
LR  - 20220410
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Print)
IS  - 1043-2760 (Linking)
VI  - 25
IP  - 2
DP  - 2014 Feb
TI  - BDNF mediates adaptive brain and body responses to energetic challenges.
PG  - 89-98
LID - S1043-2760(13)00178-1 [pii]
LID - 10.1016/j.tem.2013.10.006 [doi]
AB  - Emerging findings suggest that brain-derived neurotrophic factor (BDNF) serves 
      widespread roles in regulating energy homeostasis by controlling patterns of 
      feeding and physical activity, and by modulating glucose metabolism in peripheral 
      tissues. BDNF mediates the beneficial effects of energetic challenges such as 
      vigorous exercise and fasting on cognition, mood, cardiovascular function, and on 
      peripheral metabolism. By stimulating glucose transport and mitochondrial 
      biogenesis BDNF bolsters cellular bioenergetics and protects neurons against 
      injury and disease. By acting in the brain and periphery, BDNF increases insulin 
      sensitivity and parasympathetic tone. Genetic factors, a 'couch potato' 
      lifestyle, and chronic stress impair BDNF signaling, and this may contribute to 
      the pathogenesis of metabolic syndrome. Novel BDNF-focused interventions are 
      being developed for obesity, diabetes, and neurological disorders.
CI  - Published by Elsevier Ltd.
FAU - Marosi, Krisztina
AU  - Marosi K
AD  - Laboratory of Neurosciences, National Institute on Aging Intramural Research 
      Program, Baltimore, MD, USA.
FAU - Mattson, Mark P
AU  - Mattson MP
AD  - Laboratory of Neurosciences, National Institute on Aging Intramural Research 
      Program, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University 
      School of Medicine, Baltimore, MD 21205, USA. Electronic address: 
      mark.mattson@nih.gov.
LA  - eng
GR  - P30 DK079637/DK/NIDDK NIH HHS/United States
GR  - ZIA AG000315-12/Intramural NIH HHS/United States
GR  - ZIA AG000315-13/Intramural NIH HHS/United States
GR  - ZIA AG000317-12/Intramural NIH HHS/United States
GR  - ZIA AG000314-13/Intramural NIH HHS/United States
GR  - ZIA AG000317-13/Intramural NIH HHS/United States
GR  - ZIA AG000314-12/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20131219
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adaptation, Biological
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*physiology
MH  - Circadian Rhythm/physiology
MH  - Cognition
MH  - Energy Metabolism/*physiology
MH  - Heart Rate/drug effects
MH  - Homeostasis/drug effects
MH  - Humans
MH  - Insulin Resistance
MH  - Motor Activity
MH  - Neuronal Plasticity/physiology
MH  - Signal Transduction
PMC - PMC3915771
MID - NIHMS551193
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - BDNF
OT  - diabetes
OT  - exercise
OT  - glucocorticoid
OT  - insulin resistance
OT  - learning and memory
OT  - obesity
EDAT- 2013/12/24 06:00
MHDA- 2014/09/26 06:00
PMCR- 2015/02/01
CRDT- 2013/12/24 06:00
PHST- 2013/09/01 00:00 [received]
PHST- 2013/10/14 00:00 [revised]
PHST- 2013/10/24 00:00 [accepted]
PHST- 2013/12/24 06:00 [entrez]
PHST- 2013/12/24 06:00 [pubmed]
PHST- 2014/09/26 06:00 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - S1043-2760(13)00178-1 [pii]
AID - 10.1016/j.tem.2013.10.006 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2014 Feb;25(2):89-98. doi: 10.1016/j.tem.2013.10.006. 
      Epub 2013 Dec 19.