PMID- 24361407
OWN - NLM
STAT- MEDLINE
DCOM- 20141028
LR  - 20171116
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 65
DP  - 2014 Mar
TI  - Luteolin and luteolin-7-O-glucoside strengthen antioxidative potential through 
      the modulation of Nrf2/MAPK mediated HO-1 signaling cascade in RAW 264.7 cells.
PG  - 70-5
LID - S0278-6915(13)00839-9 [pii]
LID - 10.1016/j.fct.2013.12.017 [doi]
AB  - It has been understood that glycosidic forms of flavonoids were hydrolyzed by gut 
      bacteria and absorbed as aglycones. However, several reports suggested that 
      glycosides were partly absorbed without hydrolysis and remained biologically 
      active. In this study, we evaluated the antioxidative potential of luteolin and 
      luteolin-7-O-glucoside, glycosidic form of luteolin, against the oxidative damage 
      and compared their antioxidative mechanisms in RAW 264.7 cells. Heme oxygenase-1 
      (HO-1), one of the phase II enzymes showing an antioxidative activity, was 
      potently induced by luteolin and luteolin-7-O-glucoside treatment, which was in 
      accordance with the translocated nuclear factor-erythroid 2 p45-related factor 2 
      (Nrf2) into nucleus. Moreover, luteolin and the luteolin-7-O-glucoside activated 
      HO-1 expression by p38 and c-Jun NH2-terminal kinase (JNK) regulation. In order 
      to identify the antioxidation potential by HO-1, tert-butyl hydroperoxide 
      (t-BHP)-induced oxidative damage was applied and ameliorated by luteolin and the 
      luteolin-7-O-glucoside treatment in a dose dependent manner, which was confirmed 
      by HO-1 selective inhibitor and inducer, tin protoporphyrin (SnPP) and cobalt 
      protoporphyrin (CoPP), respectively. Consequently, luteolin and 
      luteolin-7-O-glucoside potently strengthen the HO-1-mediated antioxidative 
      potential through the modulation of the Nrf2/MAPK signaling pathways.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Song, Young Sun
AU  - Song YS
AD  - Department of Smart Foods and Drugs, Inje University, Gimhae, Gyeongnam, Republic 
      of Korea.
FAU - Park, Chung Mu
AU  - Park CM
AD  - Department of Clinical Laboratory Science, Dong-Eui University, Busan, Republic 
      of Korea. Electronic address: cmpark@deu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131219
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Antioxidants)
RN  - 0 (Glucosides)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Nfe2l2 protein, mouse)
RN  - 98J6XDS46I (luteolin-7-glucoside)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - KUX1ZNC9J2 (Luteolin)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Cell Line
MH  - Glucosides/*pharmacology
MH  - Heme Oxygenase-1/*metabolism
MH  - Luteolin/*pharmacology
MH  - MAP Kinase Signaling System/*drug effects
MH  - Macrophages/*drug effects/metabolism
MH  - Mice
MH  - NF-E2-Related Factor 2/*metabolism
MH  - Signal Transduction/*drug effects
OTO - NOTNLM
OT  - Heme oxygenase-1
OT  - Luteolin
OT  - Luteolin-7-O-glucoside
OT  - Mitogen activated protein kinase
OT  - Nuclear factor-erythroid 2 p45-related factor 2
EDAT- 2013/12/24 06:00
MHDA- 2014/10/29 06:00
CRDT- 2013/12/24 06:00
PHST- 2013/09/17 00:00 [received]
PHST- 2013/11/22 00:00 [revised]
PHST- 2013/12/13 00:00 [accepted]
PHST- 2013/12/24 06:00 [entrez]
PHST- 2013/12/24 06:00 [pubmed]
PHST- 2014/10/29 06:00 [medline]
AID - S0278-6915(13)00839-9 [pii]
AID - 10.1016/j.fct.2013.12.017 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2014 Mar;65:70-5. doi: 10.1016/j.fct.2013.12.017. Epub 2013 
      Dec 19.