PMID- 24361910
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20140203
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 261
DP  - 2014 Mar 15
TI  - Brain-derived neurotrophic factor signalling mediates the antidepressant-like 
      effect of piperine in chronically stressed mice.
PG  - 140-5
LID - S0166-4328(13)00763-8 [pii]
LID - 10.1016/j.bbr.2013.12.020 [doi]
AB  - Previous studies in our laboratory have demonstrated that piperine produced 
      antidepressant-like action in various mouse models of behavioral despair. This 
      study aimed to investigate the role of brain-derived neurotrophic factor (BDNF) 
      signalling in the antidepressant-like effect of piperine in mice exposed to 
      chronic unpredictable mild stress (CUMS). The results showed that CUMS caused 
      depression-like behavior in mice, as indicated by the significant decrease in 
      sucrose consumption and increase in immobility time in the forced swim test. It 
      was also found that BDNF protein expression in the hippocampus and frontal cortex 
      were significantly decreased in CUMS-treated mice. Chronic treatment of piperine 
      at the dose of 10mg/kg significantly ameliorated behavioural deficits of 
      CUMS-treated mice in the sucrose preference test and forced swim test. Piperine 
      treatment also significantly decreased immobility time in the forced swim test in 
      naive mice. In parallel, chronic piperine treatment significantly increased BDNF 
      protein expression in the hippocampus and frontal cortex of both naive and 
      CUMS-treated mice. In addition, inhibition of BDNF signalling by injection of 
      K252a, an inhibitor of the BDNF receptor TrkB, significantly blocked the 
      antidepressant-like effect of piperine in the sucrose preference test and forced 
      swim test of CUMS-treated mice. Taken together, this study suggests that BDNF 
      signalling is an essential mediator for the antidepressant-like effect of 
      piperine.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Mao, Qing-Qiu
AU  - Mao QQ
AD  - School of Chinese Medicine, The Chinese University of Hong Kong, Shatin N.T., 
      Hong Kong; College of Pharmacy, Zhejiang Chinese Medicine University, Hangzhou, 
      310053, Zhejiang, China.
FAU - Huang, Zhen
AU  - Huang Z
AD  - College of Pharmacy, Zhejiang Chinese Medicine University, Hangzhou, 310053, 
      Zhejiang, China.
FAU - Zhong, Xiao-Ming
AU  - Zhong XM
AD  - College of Pharmacy, Zhejiang Chinese Medicine University, Hangzhou, 310053, 
      Zhejiang, China.
FAU - Xian, Yan-Fang
AU  - Xian YF
AD  - School of Chinese Medicine, The Chinese University of Hong Kong, Shatin N.T., 
      Hong Kong.
FAU - Ip, Siu-Po
AU  - Ip SP
AD  - School of Chinese Medicine, The Chinese University of Hong Kong, Shatin N.T., 
      Hong Kong. Electronic address: paulip@cuhk.edu.hk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131219
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Alkaloids)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Benzodioxoles)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Indole Alkaloids)
RN  - 0 (Piperidines)
RN  - 0 (Polyunsaturated Alkamides)
RN  - 0 (Sweetening Agents)
RN  - 57-50-1 (Sucrose)
RN  - 97161-97-2 (staurosporine aglycone)
RN  - U71XL721QK (piperine)
SB  - IM
MH  - Alkaloids/*therapeutic use
MH  - Animals
MH  - Antidepressive Agents/*therapeutic use
MH  - Benzodioxoles/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Carbazoles/pharmacology
MH  - Chronic Disease
MH  - Disease Models, Animal
MH  - Enzyme Inhibitors/pharmacology
MH  - Food Preferences/drug effects
MH  - Indole Alkaloids/pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Piperidines/*therapeutic use
MH  - Polyunsaturated Alkamides/*therapeutic use
MH  - Signal Transduction/*drug effects
MH  - Stress, Psychological/*drug therapy/*metabolism
MH  - Sucrose/administration & dosage
MH  - Sweetening Agents/administration & dosage
MH  - Time Factors
OTO - NOTNLM
OT  - Antidepressant
OT  - Brain-derived neurotrophic factor
OT  - Chronic unpredictable mild stress
OT  - Mice
OT  - Piperine
EDAT- 2013/12/24 06:00
MHDA- 2014/10/07 06:00
CRDT- 2013/12/24 06:00
PHST- 2013/10/09 00:00 [received]
PHST- 2013/12/06 00:00 [revised]
PHST- 2013/12/11 00:00 [accepted]
PHST- 2013/12/24 06:00 [entrez]
PHST- 2013/12/24 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - S0166-4328(13)00763-8 [pii]
AID - 10.1016/j.bbr.2013.12.020 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 Mar 15;261:140-5. doi: 10.1016/j.bbr.2013.12.020. Epub 2013 
      Dec 19.