PMID- 24362477
OWN - NLM
STAT- MEDLINE
DCOM- 20140328
LR  - 20151119
IS  - 0126-8635 (Print)
IS  - 0126-8635 (Linking)
VI  - 35
IP  - 2
DP  - 2013 Dec
TI  - Cytokeratin immunoreactivity in Ewing sarcoma/ primitive neuroectodermal tumour.
PG  - 139-45
AB  - Ewing sarcoma (ES)/ primitive neuroectodermal tumour (PNET) is an aggressive 
      malignant neoplasm affecting mainly children and young adults. The tumour is 
      included with other primitive neoplasms under the category of small round cell 
      tumour. Cytokeratin expression in ES/PNET has been described in sporadic case 
      reports as well as a few systemic series. We studied this feature in Malaysian 
      patients diagnosed in University Malaya Medical Centre on the basis of typical 
      morphology and immunohistochemical assays. Immunohistochemical staining for 
      AE1/AE3 and MNF116 were performed in 43 cases. Cytokeratin was expressed in 17 
      cases (39.5%) in focal, intermediate or diffuse patterns. There was no 
      significant association between cytokeratin immunoreactivity and the following 
      parameters: patient age, sex, skeletal and extraskeletal primary location as well 
      as primary, metastastic or recurrent tumours or chemotherapy treatment. A 
      significant association between cytokeratin and neuron specific enolase (NSE) 
      expression was demonstrated. Our study supports evidence of epithelial 
      differentiation in ES/PNET and emphasizes that the expression of cytokeratin does 
      not exclude ES/PNET in the differential diagnosis of small round cell tumours.
FAU - Elbashier, S H A
AU  - Elbashier SH
AD  - University Malaya, Faculty of Medicine, Pathology Department, Jalan Universiti, 
      50603 Kuala Lumpur, Malaysia.
FAU - Nazarina, A R
AU  - Nazarina AR
FAU - Looi, L M
AU  - Looi LM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Malaysia
TA  - Malays J Pathol
JT  - The Malaysian journal of pathology
JID - 8101177
RN  - 0 (Biomarkers, Tumor)
RN  - 68238-35-7 (Keratins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Keratins/analysis/*biosynthesis
MH  - Malaysia
MH  - Male
MH  - Middle Aged
MH  - Neuroectodermal Tumors, Primitive/*metabolism/pathology
MH  - Sarcoma, Ewing/*metabolism/pathology
MH  - Young Adult
EDAT- 2013/12/24 06:00
MHDA- 2014/03/29 06:00
CRDT- 2013/12/24 06:00
PHST- 2013/12/24 06:00 [entrez]
PHST- 2013/12/24 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
PST - ppublish
SO  - Malays J Pathol. 2013 Dec;35(2):139-45.