PMID- 24364208
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20171116
IS  - 0032-5422 (Print)
IS  - 0032-5422 (Linking)
VI  - 59
IP  - 3
DP  - 2013
TI  - [Type 2 diabetes mellitus impairs endothelial progenitor cells functions].
PG  - 257-66
AB  - Type 2 diabetes mellitus (T2DM) is a metabolic disease caused by insulin 
      resistance that leads to changes in glucose metabolism. Importantly, both insulin 
      resistance and hyperglycemia are present in T2DM patients as a hallmarks of 
      metabolic syndrome. They negatively affect functions of many cells, for example 
      endothelial cells. Endothelial progenitor cells (EPC) is a population of 
      mononuclear cells that expresses endothelial and progenitor markers. EPC are also 
      characterized by ability to form tubes on matrigel, outgrowth into mature 
      endothelial cells, produce proangiogenic factors or take part in the blood 
      vessels formation. Upon injury endothelial progenitor cells are mobilized from 
      bone marrow, home to injured site and take part in vessels formation. It was 
      shown however, that functions of EPC in T2DM patients are impaired. In this 
      review we focused on the T2DM and its detrimental effects on EPC biology. taking 
      also into account the beneficiary role of anti-diabetic drugs. Decreased number 
      and impaired functions of EPC in T2DM patients might lead to increased frequency 
      of cardiovascular incidents and development of micro- or macroangiopathies.
FAU - Kotlinowski, Jerzy
AU  - Kotlinowski J
AD  - Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and 
      Biotechnology, Jagiellonian University, 7 Gronostajowa St., 30-387 Krakow, 
      Poland.
FAU - Dulak, Jozef
AU  - Dulak J
AD  - Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and 
      Biotechnology, Jagiellonian University, 7 Gronostajowa St., 30-387 Krakow, 
      Poland.
FAU - Jozkowicz, Alicja
AU  - Jozkowicz A
AD  - Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and 
      Biotechnology, Jagiellonian University, 7 Gronostajowa St., 30-387 Krakow, 
      Poland.
LA  - pol
PT  - Journal Article
PT  - Review
TT  - Cukrzyca typu 2 uposledza funkcjonowanie komorek progenitorowych srodblonka.
PL  - Poland
TA  - Postepy Biochem
JT  - Postepy biochemii
JID - 0023525
SB  - IM
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Diabetic Angiopathies/etiology/*metabolism/prevention & control
MH  - Endothelial Cells/*metabolism
MH  - Humans
MH  - Hyperglycemia/metabolism
MH  - Insulin Resistance
MH  - Metabolic Syndrome/metabolism
MH  - Stem Cells/*metabolism
EDAT- 2013/12/25 06:00
MHDA- 2014/01/24 06:00
CRDT- 2013/12/25 06:00
PHST- 2013/12/25 06:00 [entrez]
PHST- 2013/12/25 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
PST - ppublish
SO  - Postepy Biochem. 2013;59(3):257-66.