PMID- 24365186
OWN - NLM
STAT- MEDLINE
DCOM- 20150107
LR  - 20191027
IS  - 1996-3181 (Electronic)
IS  - 1871-5273 (Linking)
VI  - 13
IP  - 3
DP  - 2014 Apr
TI  - Humanin: a possible linkage between Alzheimer's disease and type 2 diabetes.
PG  - 543-52
AB  - The prevalence of Alzheimer's disease (AD) is higher among type 2 diabetes 
      mellitus (T2DM) patients. In T2DM patients, the progression of AD is more rapid. 
      Furthermore, several pathophysiological pathways are common to AD and T2DM. 
      Humanin is a recently introduced, mitochondrial-derived peptide with 
      neuroprotective effects. Humanin can alter the mechanisms involved in AD and T2DM 
      pathogenesis. Insulin resistance as well as oxidative stress has been shown to be 
      associated with increased amyloid deposition in brain neurons and islet beta 
      cells. Moreover, advanced glycation end products and lipid metabolism disorders 
      are common pathways of oxidative stress and low-grade systemic inflammation in AD 
      and T2DM. These common pathways may explain AD and T2DM pathogenesis and suggest 
      common treatments for both diseases. Treatments for T2DM and AD attempt to slow 
      cognitive decline, and recent investigations have focused on agents that may 
      alter pathways common to AD and T2DM pathogenesis. Non-steroidal antiinflammatory 
      drugs, such as interleukin-1 antagonists and statins, are possible drug 
      candidates for both AD and T2DM.
FAU - Mahboobi, Hamidreza
AU  - Mahboobi H
FAU - Golmirzaei, Javad
AU  - Golmirzaei J
FAU - Gan, Siew H
AU  - Gan SH
FAU - Jalalian, Mehrdad
AU  - Jalalian M
FAU - Kamal, Mohammad A
AU  - Kamal MA
AD  - Hamidreza Mahboobi, Hormozgan University of Medical Sciences (HUMS), Bandar 
      Abbas, Hormozgan, Iran. hamidrezamahboobi@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - CNS Neurol Disord Drug Targets
JT  - CNS & neurological disorders drug targets
JID - 101269155
RN  - 0 (Apolipoproteins E)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (humanin)
SB  - IM
MH  - *Alzheimer Disease/epidemiology/genetics/metabolism
MH  - Apolipoproteins E/genetics
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics/metabolism
MH  - Humans
MH  - Insulin Resistance
MH  - Intracellular Signaling Peptides and Proteins/*genetics/*metabolism
MH  - Oxidative Stress
EDAT- 2013/12/25 06:00
MHDA- 2015/01/08 06:00
CRDT- 2013/12/25 06:00
PHST- 2013/05/28 00:00 [received]
PHST- 2013/10/09 00:00 [revised]
PHST- 2013/10/09 00:00 [accepted]
PHST- 2013/12/25 06:00 [entrez]
PHST- 2013/12/25 06:00 [pubmed]
PHST- 2015/01/08 06:00 [medline]
AID - CNSNDDT-EPUB-58213 [pii]
AID - 10.2174/1871527312666131223110147 [doi]
PST - ppublish
SO  - CNS Neurol Disord Drug Targets. 2014 Apr;13(3):543-52. doi: 
      10.2174/1871527312666131223110147.