PMID- 24365420
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20191210
IS  - 0072-9752 (Print)
IS  - 0072-9752 (Linking)
VI  - 121
DP  - 2014
TI  - Neurologic complications of bone marrow transplantation.
PG  - 1295-304
LID - B978-0-7020-4088-7.00088-2 [pii]
LID - 10.1016/B978-0-7020-4088-7.00088-2 [doi]
AB  - Although bone marrow transplantation has been recognized as an effective therapy 
      for malignant and nonmalignant blood disorders, the modality has also been 
      associated with side-effects and complications. Among these adverse events, 
      neurologic complications emerged as an important and frequent source of 
      treatment-related morbidity and mortality. The survival of patients who died from 
      complications related to central nervous system abnormalities appears to be 
      shorter compared to those who died from non-neurological complications. The 
      incidence of neurologic complications appears to correlate with the degree of 
      human leukocyte antigen (HLA) disparity and the risk status of the underlying 
      disease. Nonrelapse mortality associated with reduced intensity regimens is lower 
      compared to myeloablative conditioning regimens. However, reduced intensity 
      regimens are still associated with significant incidence of complications, 
      including graft-versus-host disease, opportunistic infections, organ toxicity, 
      and neurologic complications. Complications of sepsis-related encephalopathy in 
      mechanically ventilated patients are frequently either overlooked or 
      misdiagnosed. Obtaining a microbiological diagnosis through body fluid cultures 
      or tissue identification is important in order to identify the source of 
      infection and guide an effective antimicrobial therapy. However, pursuing a 
      microbiological diagnosis must not delay the administration of antibiotics and 
      resuscitation of a patient with septic shock.
CI  - (c) 2014 Elsevier B.V. All rights reserved.
FAU - Rodriguez, Tulio E
AU  - Rodriguez TE
AD  - Bone Marrow Transplantation Program, Loyola University Medical Center and 
      Department of Medicine, Loyola University Chicago, Stritch School of Medicine, 
      Chicago, IL, USA. Electronic address: trodriguez@lumc.edu.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Handb Clin Neurol
JT  - Handbook of clinical neurology
JID - 0166161
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Brain Diseases/etiology
MH  - Graft vs Host Disease/physiopathology/psychology/therapy
MH  - Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Humans
MH  - Immunosuppressive Agents/adverse effects
MH  - Infections/epidemiology/etiology
MH  - Nervous System Diseases/diagnosis/*etiology/therapy
MH  - Postoperative Complications/chemically induced/epidemiology
OTO - NOTNLM
OT  - Neurologic
OT  - bone marrow
OT  - calcineurin inhibitors
OT  - complications
OT  - drugs
OT  - encephalopathies
OT  - infections
OT  - stem cell
OT  - total body irradiation
OT  - transplantation
EDAT- 2013/12/25 06:00
MHDA- 2014/04/20 06:00
CRDT- 2013/12/25 06:00
PHST- 2013/12/25 06:00 [entrez]
PHST- 2013/12/25 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
AID - B978-0-7020-4088-7.00088-2 [pii]
AID - 10.1016/B978-0-7020-4088-7.00088-2 [doi]
PST - ppublish
SO  - Handb Clin Neurol. 2014;121:1295-304. doi: 10.1016/B978-0-7020-4088-7.00088-2.