PMID- 24366237
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20211021
IS  - 1420-9071 (Electronic)
IS  - 1420-682X (Print)
IS  - 1420-682X (Linking)
VI  - 71
IP  - 10
DP  - 2014 May
TI  - Genetic dissection of dendritic cell homeostasis and function: lessons from cell 
      type-specific gene ablation.
PG  - 1893-906
LID - 10.1007/s00018-013-1534-7 [doi]
AB  - Dendritic cells (DCs) are a heterogeneous cell population of great importance in 
      the immune system. The emergence of new genetic technology utilizing the CD11c 
      promoter and Cre recombinase has facilitated the dissection of functional 
      significance and molecular regulation of DCs in immune responses and homeostasis 
      in vivo. For the first time, this strategy allows observation of the effects of 
      DC-specific gene deletion on immune system function in an intact organism. In 
      this review, we present the latest findings from studies using the Cre 
      recombinase system for cell type-specific deletion of key molecules that mediate 
      DC homeostasis and function. Our focus is on the molecular pathways that 
      orchestrate DC life span, migration, antigen presentation, pattern recognition, 
      and cytokine production and signaling.
FAU - Karmaus, Peer W F
AU  - Karmaus PW
AD  - Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas 
      Place, Memphis, TN, 38105-3678, USA.
FAU - Chi, Hongbo
AU  - Chi H
LA  - eng
GR  - R01 AI101407/AI/NIAID NIH HHS/United States
GR  - R01 NS064599/NS/NINDS NIH HHS/United States
GR  - R21 AI094089/AI/NIAID NIH HHS/United States
GR  - R37 AI105887/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20131224
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.7.- (Cre recombinase)
RN  - EC 2.7.7.- (Integrases)
SB  - IM
MH  - Antigen Presentation
MH  - Apoptosis
MH  - CD4-Positive T-Lymphocytes/immunology/metabolism
MH  - Cytokines/metabolism
MH  - Dendritic Cells/cytology/immunology/*metabolism
MH  - Gene Deletion
MH  - Integrases/genetics/metabolism
MH  - Receptors, Cell Surface/metabolism
MH  - Signal Transduction
MH  - Transcription Factors/genetics/metabolism
PMC - PMC3999183
MID - NIHMS551653
EDAT- 2013/12/25 06:00
MHDA- 2014/06/10 06:00
PMCR- 2015/05/01
CRDT- 2013/12/25 06:00
PHST- 2013/08/22 00:00 [received]
PHST- 2013/11/25 00:00 [accepted]
PHST- 2013/12/25 06:00 [entrez]
PHST- 2013/12/25 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - 10.1007/s00018-013-1534-7 [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2014 May;71(10):1893-906. doi: 10.1007/s00018-013-1534-7. Epub 
      2013 Dec 24.