PMID- 24366514
OWN - NLM
STAT- MEDLINE
DCOM- 20141117
LR  - 20140319
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Linking)
VI  - 75
IP  - 4
DP  - 2014 Apr
TI  - Airway and vascular maturation stimulated by tracheal occlusion do not correlate 
      in the rabbit model of diaphragmatic hernia.
PG  - 487-92
LID - 10.1038/pr.2013.244 [doi]
AB  - BACKGROUND: In animal models of congenital diaphragmatic hernia (CDH), tracheal 
      occlusion (TO) has induced maturation of both airway spaces and vascular 
      structures. Airway and vascular response to TO are assumed to occur in parallel. 
      This study aims to describe and measure the relationship between airway and 
      vascular maturation induced by TO. METHODS: A rabbit model of CDH on gestational 
      day (GD) 23 and TO on GD 28 (term = GD 31) has been used. Two study groups have 
      been defined: DH (diaphragmatic hernia) and TO (DH treated with TO). Animals were 
      collected on GD 30 and blood flow data of the pulmonary artery (pulsatility index 
      (PI) and fractional moving blood volume) were ultrasonographically measured. Lung 
      morphometry consisted of measurements of radial alveolar count (RAC) and arterial 
      muscular thickness. RESULTS: Animals in the DH group (n = 9) had the worst 
      hemodynamic parameters; their lungs were hypoplastic and had the thickest 
      arterial muscular layer. Animals in the TO group (n = 10) had all these effects 
      reversed. There were no correlations among hemodynamic, airway, and vascular 
      parameters, except for RAC and PI (r = -0.528, P = 0.043). CONCLUSION: Airway and 
      vascular maturation after TO appear to be uncorrelated effects. TO could trigger 
      several pathways that separately regulate airway and vascular responses.
FAU - Prat Ortells, Jordi
AU  - Prat Ortells J
AD  - Department of Pediatric Surgery, Hospital Sant Joan de Deu-Hospital Clinic, 
      Universitat de Barcelona, Barcelona, Spain.
FAU - Albert, Asteria
AU  - Albert A
AD  - Department of Pediatric Surgery, Hospital Sant Joan de Deu-Hospital Clinic, 
      Universitat de Barcelona, Barcelona, Spain.
FAU - Tarrado, Xavier
AU  - Tarrado X
AD  - Department of Pediatric Surgery, Hospital Sant Joan de Deu-Hospital Clinic, 
      Universitat de Barcelona, Barcelona, Spain.
FAU - Krauel, Lucas
AU  - Krauel L
AD  - Department of Pediatric Surgery, Hospital Sant Joan de Deu-Hospital Clinic, 
      Universitat de Barcelona, Barcelona, Spain.
FAU - Cruz, Rogelio
AU  - Cruz R
AD  - Fetal and Perinatal Medicine Research Group, Department of Maternal-Fetal 
      Medicine, Hospital Clinic-IDIBAPS, Universitat de Barcelona and Centre for 
      Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.
FAU - Moreno-Alvarez, Oscar
AU  - Moreno-Alvarez O
AD  - Fetal and Perinatal Medicine Research Group, Department of Maternal-Fetal 
      Medicine, Hospital Clinic-IDIBAPS, Universitat de Barcelona and Centre for 
      Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.
FAU - Fuste, Victoria
AU  - Fuste V
AD  - Department of Pathology, Hospital Clinic, Universitat de Barcelona, Barcelona, 
      Spain.
FAU - Castanon, Montserrat
AU  - Castanon M
AD  - Department of Pediatric Surgery, Hospital Sant Joan de Deu-Hospital Clinic, 
      Universitat de Barcelona, Barcelona, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131223
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
SB  - IM
MH  - Animals
MH  - Blood Vessels/*pathology
MH  - *Disease Models, Animal
MH  - Hemodynamics
MH  - Hernia, Diaphragmatic/*pathology/physiopathology
MH  - Rabbits
MH  - Trachea/blood supply/*pathology
EDAT- 2013/12/25 06:00
MHDA- 2014/11/18 06:00
CRDT- 2013/12/25 06:00
PHST- 2012/11/20 00:00 [received]
PHST- 2013/07/29 00:00 [accepted]
PHST- 2013/12/25 06:00 [entrez]
PHST- 2013/12/25 06:00 [pubmed]
PHST- 2014/11/18 06:00 [medline]
AID - pr2013244 [pii]
AID - 10.1038/pr.2013.244 [doi]
PST - ppublish
SO  - Pediatr Res. 2014 Apr;75(4):487-92. doi: 10.1038/pr.2013.244. Epub 2013 Dec 23.