PMID- 24366608 OWN - NLM STAT- MEDLINE DCOM- 20141028 LR - 20221207 IS - 1559-1174 (Electronic) IS - 1535-1084 (Linking) VI - 16 IP - 1 DP - 2014 Mar TI - Effect of the BDNF Val66Met polymorphism on regional gray matter volumes and cognitive function in the Chinese population. PG - 127-36 LID - 10.1007/s12017-013-8265-7 [doi] AB - The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is common and influences the activity-dependent secretion of BDNF, which is critical for neuronal plasticity and survival. This study investigated the genetic effect of the BDNF Val66Met polymorphism on cognitive function and regional gray matter (GM) volume in a healthy Chinese population (n = 330). Voxel-based morphometry (VBM)-optimized analysis was used. There was no significant difference in the neuropsychological performances among the three BDNF genotypic groups. VBM analyses demonstrated that Met homozygotes had greater GM volumes than Val homozygotes in the left medial frontal gyrus, the left middle temporal gyrus, the left cerebellum, and the right middle temporal gyrus, and had larger GM volumes than Val/Met heterozygotes in the left middle temporal gyrus, the left inferior temporal gyrus, and the right superior frontal gyrus. Our findings suggest that the presence of two Met alleles has a protective effect on regional GM volumes in the Chinese population. FAU - Liu, Mu-En AU - Liu ME AD - Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan. FAU - Huang, Chu-Chung AU - Huang CC FAU - Chen, Mu-Hong AU - Chen MH FAU - Yang, Albert C AU - Yang AC FAU - Tu, Pei-Chi AU - Tu PC FAU - Yeh, Heng-Liang AU - Yeh HL FAU - Hong, Chen-Jee AU - Hong CJ FAU - Chen, Jin-Fan AU - Chen JF FAU - Hwang, Jen-Ping AU - Hwang JP FAU - Lin, Ching-Po AU - Lin CP FAU - Tsai, Shih-Jen AU - Tsai SJ LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20131224 PL - United States TA - Neuromolecular Med JT - Neuromolecular medicine JID - 101135365 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Alleles MH - Amino Acid Substitution MH - Asian People/*genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - Cognition MH - Female MH - Frontal Lobe/*anatomy & histology MH - Genotype MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Neuropsychological Tests MH - Organ Size MH - *Polymorphism, Single Nucleotide MH - Reference Values MH - Taiwan MH - Temporal Lobe/*anatomy & histology MH - Young Adult EDAT- 2013/12/25 06:00 MHDA- 2014/10/29 06:00 CRDT- 2013/12/25 06:00 PHST- 2013/04/26 00:00 [received] PHST- 2013/09/10 00:00 [accepted] PHST- 2013/12/25 06:00 [entrez] PHST- 2013/12/25 06:00 [pubmed] PHST- 2014/10/29 06:00 [medline] AID - 10.1007/s12017-013-8265-7 [doi] PST - ppublish SO - Neuromolecular Med. 2014 Mar;16(1):127-36. doi: 10.1007/s12017-013-8265-7. Epub 2013 Dec 24.