PMID- 24367510
OWN - NLM
STAT- MEDLINE
DCOM- 20141008
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 12
DP  - 2013
TI  - Depression-like effect of prenatal buprenorphine exposure in rats.
PG  - e82262
LID - 10.1371/journal.pone.0082262 [doi]
LID - e82262
AB  - Studies indicate that perinatal opioid exposure produces a variety of short- and 
      long-term neurobehavioral consequences. However, the precise modes of action are 
      incompletely understood. Buprenorphine, a mixed agonist/antagonist at the opioid 
      receptors, is currently being used in clinical trials for managing pregnant 
      opioid addicts. This study provides evidence of depression-like consequence 
      following prenatal exposure to supra-therapeutic dose of buprenorphine and sheds 
      light on potential mechanisms of action in a rat model involving administration 
      of intraperitoneal injection to pregnant Sprague-Dawley rats starting from 
      gestation day 7 and lasting for 14 days. Results showed that pups at postnatal 
      day 21 but not the dams had worse parameters of depression-like neurobehaviors 
      using a forced swimming test and tail suspension test, independent of gender. 
      Neurobehavioral changes were accompanied by elevation of oxidative stress, 
      reduction of plasma levels of brain-derived neurotrophic factor (BDNF) and 
      serotonin, and attenuation of tropomyosin-related kinase receptor type B (TrkB) 
      phosphorylation, extracellular signal-regulated kinase (ERK) phosphorylation, 
      protein kinase A activity, cAMP response element-binding protein (CREB) 
      phosphorylation, and CREB DNA-binding activity. Since BDNF/serotonin and CREB 
      signaling could orchestrate a positive feedback loop, our findings suggest that 
      the induction of oxidative stress, reduction of BDNF and serotonin expression, 
      and attenuation of CREB signaling induced by prenatal exposure to 
      supra-therapeutic dose of buprenorphine provide evidence of potential mechanism 
      for the development of depression-like neurobehavior.
FAU - Hung, Chih-Jen
AU  - Hung CJ
AD  - Department of Anesthesiology, Taichung Veterans General Hospital, Taichung, 
      Taiwan, ROC ; Graduate School of Nursing, HungKuang University, Taichung, Taiwan, 
      ROC.
FAU - Wu, Chih-Cheng
AU  - Wu CC
AD  - Department of Anesthesiology, Taichung Veterans General Hospital, Taichung, 
      Taiwan, ROC ; Department of Financial and Computational Mathematics, Providence 
      University, Taichung, Taiwan, ROC.
FAU - Chen, Wen-Ying
AU  - Chen WY
AD  - Department of Veterinary Medicine, National Chung Hsing University, Taichung, 
      Taiwan, ROC.
FAU - Chang, Cheng-Yi
AU  - Chang CY
AD  - Department of Surgery, Fong Yuan Hospital, Taichung, Taiwan, ROC.
FAU - Kuan, Yu-Hsiang
AU  - Kuan YH
AD  - Department of Pharmacology, Chung Shan Medical University, Taichung, Taiwan, ROC.
FAU - Pan, Hung-Chuan
AU  - Pan HC
AD  - Department of Neurosurgery, Research, Taichung Veterans General Hospital, 
      Taichung, Taiwan, ROC ; Faculty of Medicine, School of Medicine, National 
      Yang-Ming University, Taipei, Taiwan, ROC.
FAU - Liao, Su-Lan
AU  - Liao SL
AD  - Department of Education and Research, Taichung Veterans General Hospital, 
      Taichung, Taiwan, ROC.
FAU - Chen, Chun-Jung
AU  - Chen CJ
AD  - Graduate School of Nursing, HungKuang University, Taichung, Taiwan, ROC ; 
      Department of Education and Research, Taichung Veterans General Hospital, 
      Taichung, Taiwan, ROC ; Institute of Biomedical Sciences, National Chung Hsing 
      University, Taichung, Taiwan, ROC ; Center for General Education, Tunghai 
      University, Taichung, Taiwan, ROC.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131218
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 333DO1RDJY (Serotonin)
RN  - 40D3SCR4GZ (Buprenorphine)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Buprenorphine/*pharmacology
MH  - Catalase/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Female
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
PMC - PMC3867331
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/12/25 06:00
MHDA- 2014/10/09 06:00
PMCR- 2013/12/18
CRDT- 2013/12/25 06:00
PHST- 2013/08/27 00:00 [received]
PHST- 2013/11/01 00:00 [accepted]
PHST- 2013/12/25 06:00 [entrez]
PHST- 2013/12/25 06:00 [pubmed]
PHST- 2014/10/09 06:00 [medline]
PHST- 2013/12/18 00:00 [pmc-release]
AID - PONE-D-13-35354 [pii]
AID - 10.1371/journal.pone.0082262 [doi]
PST - epublish
SO  - PLoS One. 2013 Dec 18;8(12):e82262. doi: 10.1371/journal.pone.0082262. 
      eCollection 2013.