PMID- 24367564
OWN - NLM
STAT- MEDLINE
DCOM- 20141008
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 12
DP  - 2013
TI  - Association between MCP-1 -2518A/G polymorphism and cancer risk: evidence from 19 
      case-control studies.
PG  - e82855
LID - 10.1371/journal.pone.0082855 [doi]
LID - e82855
AB  - BACKGROUND: Single nucleotide polymorphisms (SNPs) may affect the development of 
      diseases. The -2518A/G polymorphism in the regulatory region of the monocyte 
      chemo-attractant protein-1 (MCP-1) gene has been reported to be associated with 
      cancer risk. However, the results of previous studies were inconsistent. 
      Therefore, we performed a meta-analysis to obtain a more precise estimation of 
      the relationship between the -2518A/G polymorphism and cancer risk. 
      METHODOLOGY/PRINCIPAL FINDINGS: We performed a meta-analysis, including 4,162 
      cases and 5,173 controls, to evaluate the strength of the association between the 
      -2518A/G polymorphism and cancer risk. Odds ratio (OR) and 95% confidence 
      intervals (95% CIs) were used to assess the strength of association. Overall, the 
      results indicated that the -2518A/G polymorphism was not statistically associated 
      with cancer risk. However, sub-group analysis revealed that individuals with GG 
      genotypes showed an increased risk of cancer in digestive system compared with 
      carriers of the A allele (GG vs. AA: OR = 1.43, 95%CI = 1.05-1.96, 
      P(heterogeneity) = 0.08; GG vs. AG/AA: OR = 1.29, 95%CI = 1.02-1.64, 
      P(heterogeneity) = 0.14). In addition, the increased risk of GG genotype was also 
      observed in Caucasians (GG vs. AG/AA: OR = 1.81, 95%CI = 1.10-2.96, 
      P(heterogeneity) = 0.02). CONCLUSION: This meta-analysis suggests that the MCP-1 
      -2518A/G polymorphism may have some relation to digestive system cancer 
      susceptibility or cancer development in Caucasian. Large-scale and well-designed 
      case-control studies are needed to validate the findings.
FAU - Da, Liang-Shan
AU  - Da LS
AD  - The First Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China 
      ; Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer 
      Hospital Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - Wannan Medical College, Wuhu, Anhui, China ; Department of Ultrasonic Medicine, 
      Wannan Medical College Affiliated Yijishan Hospital, Wuhu, Anhui, China.
FAU - Zhang, Shuai
AU  - Zhang S
AD  - Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer 
      Hospital Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China.
FAU - Qian, Yi-Chun
AU  - Qian YC
AD  - Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer 
      Hospital Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China.
FAU - Zhang, Qin
AU  - Zhang Q
AD  - Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer 
      Hospital Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China.
FAU - Jiang, Feng
AU  - Jiang F
AD  - Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer 
      Hospital Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China.
FAU - Xu, Lin
AU  - Xu L
AD  - Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer 
      Hospital Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20131218
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Humans
MH  - Male
MH  - Neoplasms/epidemiology/*genetics
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - White People/genetics
PMC - PMC3867394
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/12/25 06:00
MHDA- 2014/10/09 06:00
PMCR- 2013/12/18
CRDT- 2013/12/25 06:00
PHST- 2013/09/26 00:00 [received]
PHST- 2013/10/29 00:00 [accepted]
PHST- 2013/12/25 06:00 [entrez]
PHST- 2013/12/25 06:00 [pubmed]
PHST- 2014/10/09 06:00 [medline]
PHST- 2013/12/18 00:00 [pmc-release]
AID - PONE-D-13-39551 [pii]
AID - 10.1371/journal.pone.0082855 [doi]
PST - epublish
SO  - PLoS One. 2013 Dec 18;8(12):e82855. doi: 10.1371/journal.pone.0082855. 
      eCollection 2013.