PMID- 24367763
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20220317
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 3
DP  - 2013 Dec 9
TI  - Human leukocyte antigens and epstein-barr virus-associated nasopharyngeal 
      carcinoma: old associations offer new clues into the role of immunity in 
      infection-associated cancers.
PG  - 299
LID - 10.3389/fonc.2013.00299 [doi]
LID - 299
AB  - Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated tumor. 
      In addition to EBV, host genetic factors are believed to be important 
      determinants of NPC risk. Of all genes studies to date, human leukocyte antigen 
      (HLA) genes have shown the most consistent evidence for association with NPC, 
      both from candidate-gene studies and genome-wide association studies (GWAS). In 
      this report we summarize results from recent studies that evaluated the 
      association between HLA and NPC, and discuss whether findings reflect direct 
      causal associations for HLA genes and/or indirect associations that mark causal 
      associations with other genes in the gene-dense major histocompatibility (MHC) 
      region where HLA resides. We also compare GWAS results across cancer sites for 
      which strong hits in the MHC region were observed to generate new hypotheses 
      regarding the role of HLA genes in the development of EBV-associated cancers such 
      as NPC. Of note, we report that MHC associations for EBV-associated cancers (NPC, 
      EBV+ Hodgkin lymphoma) are driven by HLA class I genes. In contrast, MHC 
      associations for other viral-associated cancers (cervical cancer, hepatocellular 
      carcinoma) or other hematopoetic cancers (EBV- Hodgkin lymphoma, leukemia, 
      non-Hodgkin lymphomas) are driven by HLA class II genes, and those for other 
      solid tumors with less clear links to infections (lung, testicular, prostate 
      cancers) are driven by non-HLA genes in the MHC region. Future studies should aim 
      to better understand these patterns.
FAU - Su, Wen-Hui
AU  - Su WH
AD  - Department of Biomedical Sciences, Graduate Institute of Biomedical Sciences, 
      College of Medicine, Chang Gung University , Taoyuan , Taiwan ; Chang Gung 
      Molecular Medicine Research Center, Chang Gung University , Taoyuan , Taiwan.
FAU - Hildesheim, Allan
AU  - Hildesheim A
AD  - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and 
      Genetics, National Cancer Institute , Bethesda, MD , USA.
FAU - Chang, Yu-Sun
AU  - Chang YS
AD  - Chang Gung Molecular Medicine Research Center, Chang Gung University , Taoyuan , 
      Taiwan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131209
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC3856645
OTO - NOTNLM
OT  - EBV
OT  - HLA antigens
OT  - genome-wide association study
OT  - infection associated cancers
OT  - nasopharyngeal carcinoma
EDAT- 2013/12/25 06:00
MHDA- 2013/12/25 06:01
PMCR- 2013/01/01
CRDT- 2013/12/25 06:00
PHST- 2013/07/16 00:00 [received]
PHST- 2013/11/26 00:00 [accepted]
PHST- 2013/12/25 06:00 [entrez]
PHST- 2013/12/25 06:00 [pubmed]
PHST- 2013/12/25 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2013.00299 [doi]
PST - epublish
SO  - Front Oncol. 2013 Dec 9;3:299. doi: 10.3389/fonc.2013.00299.