PMID- 24368027 OWN - NLM STAT- MEDLINE DCOM- 20141106 LR - 20161125 IS - 1097-6795 (Electronic) IS - 0894-7317 (Linking) VI - 27 IP - 3 DP - 2014 Mar TI - Myocardial deformation imaging by two-dimensional speckle-tracking echocardiography for prediction of global and segmental functional changes after acute myocardial infarction: a comparison with late gadolinium enhancement cardiac magnetic resonance. PG - 249-57 LID - S0894-7317(13)00898-5 [pii] LID - 10.1016/j.echo.2013.11.014 [doi] AB - BACKGROUND: Myocardial deformation analysis by speckle-tracking echocardiography (STE) has been shown to accurately predict viability in patients with chronic ischemic left ventricular (LV) dysfunction. The aim of this study was to evaluate two-dimensional STE for the prediction of global and segmental LV functional changes after acute myocardial infarction (AMI) in comparison with late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR). METHODS: In 93 patients (mean age, 60 +/- 11 years) with first AMIs (55 with ST-segment elevation myocardial infarctions and 38 with non-ST-segment elevation myocardial infarctions) treated with acute percutaneous coronary intervention, global peak longitudinal strain was determined to describe global function by STE, and peak systolic circumferential and longitudinal strain was determined for segmental function analysis. LGE CMR was performed to define the amounts of global and segmental myocardial scar. STE and LGE CMR were performed within 48 hours of AMI. At 6-month follow-up, transthoracic echocardiography was repeated to determine global und segmental LV recovery and adverse LV remodeling (increase in end-systolic volume > 15%). RESULTS: Accuracy to predict global functional improvement as well as LV remodeling at 6-month follow-up after AMI was similar for STE and LGE CMR (areas under the curve, 0.715 vs 0.729 [P = .8830] and 0.806 vs 0.824 [P = .7141], respectively). Peak systolic circumferential strain < -14.2% had sensitivity of 71.6% and specificity of 58.1% to predict segmental functional improvement. Compared with LGE CMR, the predictive accuracy of transmural STE for segmental functional improvement at 6-month follow-up was lower (area under the curve, 0.788 vs 0.668; P = .0001). Predictive accuracy for segmental functional improvement could be improved by analysis of endocardial circumferential strain (area under the curve, 0.700 vs 0.668 for transmural speckle-tracking echocardiographic analysis; P = .0023). CONCLUSIONS: Two-dimensional STE allows the prediction of global functional recovery as well as LV remodeling after AMI with accuracy comparable with that of LGE CMR. Accuracy to predict segmental functional recovery using transmural deformation analysis by two-dimensional STE is inferior compared with LGE CMR but can be improved by a layer-specific analysis of endocardial deformation. CI - Copyright (c) 2014 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved. FAU - Altiok, Ertunc AU - Altiok E AD - Department of Cardiology, Pneumology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany. FAU - Tiemann, Sonja AU - Tiemann S AD - Department of Cardiology, Pneumology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany. FAU - Becker, Michael AU - Becker M AD - Department of Cardiology, Pneumology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany. FAU - Koos, Ralf AU - Koos R AD - Department of Cardiology, Pneumology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany. FAU - Zwicker, Christian AU - Zwicker C AD - Department of Cardiology, Pneumology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany. FAU - Schroeder, Jorg AU - Schroeder J AD - Department of Cardiology, Pneumology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany. FAU - Kraemer, Nils AU - Kraemer N AD - Department of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany. FAU - Schoth, Felix AU - Schoth F AD - Department of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany. FAU - Adam, Dan AU - Adam D AD - Department of Biomedical Engineering, University of Haifa, Haifa, Israel. FAU - Friedman, Zvi AU - Friedman Z AD - Department of Biomedical Engineering, University of Haifa, Haifa, Israel. FAU - Marx, Nikolaus AU - Marx N AD - Department of Cardiology, Pneumology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany. FAU - Hoffmann, Rainer AU - Hoffmann R AD - Department of Cardiology, Pneumology, Angiology and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany. Electronic address: rhoffmann@ukaachen.de. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20131222 PL - United States TA - J Am Soc Echocardiogr JT - Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography JID - 8801388 RN - 0 (Contrast Media) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Contrast Media/administration & dosage MH - Echocardiography/*methods MH - Elastic Modulus MH - Elasticity Imaging Techniques/*methods MH - Female MH - *Gadolinium DTPA/administration & dosage MH - Hardness MH - Heart Ventricles/diagnostic imaging/pathology/*physiopathology MH - Humans MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Myocardial Infarction/complications/diagnosis/*physiopathology MH - Prognosis MH - Reproducibility of Results MH - Sensitivity and Specificity MH - Ventricular Dysfunction, Left/diagnosis/etiology/*physiopathology OTO - NOTNLM OT - Acute myocardial infarction OT - Cardiac magnetic resonance OT - Echocardiography OT - Left ventricular function OT - Myocardial contraction EDAT- 2013/12/26 06:00 MHDA- 2014/11/07 06:00 CRDT- 2013/12/26 06:00 PHST- 2013/03/14 00:00 [received] PHST- 2013/12/26 06:00 [entrez] PHST- 2013/12/26 06:00 [pubmed] PHST- 2014/11/07 06:00 [medline] AID - S0894-7317(13)00898-5 [pii] AID - 10.1016/j.echo.2013.11.014 [doi] PST - ppublish SO - J Am Soc Echocardiogr. 2014 Mar;27(3):249-57. doi: 10.1016/j.echo.2013.11.014. Epub 2013 Dec 22.