PMID- 24368499
OWN - NLM
STAT- MEDLINE
DCOM- 20140910
LR  - 20211021
IS  - 1613-2246 (Electronic)
IS  - 0021-5155 (Linking)
VI  - 58
IP  - 2
DP  - 2014 Mar
TI  - Two types of acute zonal occult outer retinopathy differentiated by dark- and 
      light-adapted perimetry.
PG  - 177-87
LID - 10.1007/s10384-013-0297-x [doi]
AB  - PURPOSE: To assess the results of perimetry recorded under dark- and 
      light-adapted (DA and LA) conditions in patients with acute zonal occult outer 
      retinopathy (AZOOR) and to compare the results of electroretinography (ERG) and 
      spectral-domain optical coherence tomography (SD-OCT) in two groups of AZOOR 
      patients. METHODS: Twelve patients with AZOOR were studied. The diagnosis of 
      AZOOR was based on the results of ophthalmoscopy, Goldmann kinetic perimetry, and 
      multifocal ERGs. In addition, DA and LA perimetry, ERG, and SD-OCT were 
      performed. The patients were followed for 1-9 years. RESULTS: The patients were 
      classified into two types: type A patients (3) had a scotoma detected by both DA 
      and LA perimetry, normal or equally abnormal cone and rod ERGs, atrophy of the 
      outer nuclear layer (ONL), and disruption of the inner segment/outer segment 
      (IS/OS) junction line in the OCT images. Type B patients (7) had a scotoma that 
      was more prominent in LA than in DA perimetry and a continuous IS/OS junction 
      line in the OCT images. Two patients had characteristics of both type A and type 
      B AZOOR. CONCLUSIONS: Our findings suggest that eyes with type A AZOOR have focal 
      and severe impairment of both the rods and cones, and eyes with type B AZOOR have 
      focal and specific impairment of the cones.
FAU - Kuniyoshi, Kazuki
AU  - Kuniyoshi K
AD  - Department of Ophthalmology, Kinki University Faculty of Medicine, 377-2 
      Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan, kazuki@med.kindai.ac.jp.
FAU - Sakuramoto, Hiroyuki
AU  - Sakuramoto H
FAU - Nakao, Yuzo
AU  - Nakao Y
FAU - Matsumoto, Chota
AU  - Matsumoto C
FAU - Shimomura, Yoshikazu
AU  - Shimomura Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131226
PL  - Japan
TA  - Jpn J Ophthalmol
JT  - Japanese journal of ophthalmology
JID - 0044652
RN  - Acute zonal occult outer retinopathy
SB  - IM
MH  - Adult
MH  - Atrophy
MH  - *Dark Adaptation
MH  - Diagnosis, Differential
MH  - Electroretinography
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Light
MH  - Male
MH  - Middle Aged
MH  - Ophthalmoscopy
MH  - Photoreceptor Cells, Vertebrate/pathology
MH  - Retinal Photoreceptor Cell Inner Segment/pathology
MH  - Retinal Photoreceptor Cell Outer Segment/pathology
MH  - Scotoma/classification/*diagnosis
MH  - Tomography, Optical Coherence
MH  - Visual Field Tests/*methods
MH  - Visual Fields
MH  - White Dot Syndromes
EDAT- 2013/12/26 06:00
MHDA- 2014/09/11 06:00
CRDT- 2013/12/26 06:00
PHST- 2013/06/27 00:00 [received]
PHST- 2013/10/29 00:00 [accepted]
PHST- 2013/12/26 06:00 [entrez]
PHST- 2013/12/26 06:00 [pubmed]
PHST- 2014/09/11 06:00 [medline]
AID - 10.1007/s10384-013-0297-x [doi]
PST - ppublish
SO  - Jpn J Ophthalmol. 2014 Mar;58(2):177-87. doi: 10.1007/s10384-013-0297-x. Epub 
      2013 Dec 26.