PMID- 24368522
OWN - NLM
STAT- MEDLINE
DCOM- 20150526
LR  - 20140324
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Linking)
VI  - 46
IP  - 4
DP  - 2014 Apr
TI  - Homocysteinylation score of high-molecular weight plasma proteins.
PG  - 893-9
LID - 10.1007/s00726-013-1652-4 [doi]
AB  - Ultrafiltration rates (filterability) of protein-bound homocysteine (Hcy), unlike 
      glutathione (Glt), are significantly decreased in patients with cardiovascular 
      disorders, end-stage renal disease, and prothrombotic conditions. Reduced 
      filterability of Hcy through 300,000 MWCO PES membranes in these groups of 
      patients was observed, regardless of hyperhomocysteinemia (HHcy) degree. 
      Filterability of Hcy, but not of glutathione, was impaired in plasma 
      preparations. It is possible that the patients with impaired filterability of Hcy 
      in mixed disulfide state are characterized by increased ability of partial Hcy 
      retention by proteins and complexes with higher than albumin molecular weight. 
      These findings led us to conclude that evaluation of protein-bound Hcy 
      filterability may provide more complete diagnostic data, to interpret clinical 
      significance of HHcy. The proposed Hcy filterability test may be performed as a 
      simple laboratory procedure, in addition to conventional tests for total Hcy.
FAU - Zhloba, Alexandr A
AU  - Zhloba AA
AD  - Biochemical Department of Scientific Centre, First Pavlov State Medical 
      University of St. Petersburg, 6-8, Ul. L. Tolstogo, 197022, St. Petersburg, 
      Russia, Zhloba@mail.spbnit.ru.
FAU - Subbotina, Tatiana F
AU  - Subbotina TF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131225
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Blood Proteins)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - Homocysteinemia
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Proteins/chemistry/*metabolism
MH  - Cardiovascular Diseases/*blood/metabolism
MH  - Female
MH  - Homocysteine/*metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/metabolism
MH  - Male
MH  - Middle Aged
MH  - Molecular Weight
MH  - Protein Binding
EDAT- 2013/12/26 06:00
MHDA- 2015/05/27 06:00
CRDT- 2013/12/26 06:00
PHST- 2013/09/25 00:00 [received]
PHST- 2013/12/12 00:00 [accepted]
PHST- 2013/12/26 06:00 [entrez]
PHST- 2013/12/26 06:00 [pubmed]
PHST- 2015/05/27 06:00 [medline]
AID - 10.1007/s00726-013-1652-4 [doi]
PST - ppublish
SO  - Amino Acids. 2014 Apr;46(4):893-9. doi: 10.1007/s00726-013-1652-4. Epub 2013 Dec 
      25.