PMID- 24368883 OWN - NLM STAT- MEDLINE DCOM- 20140825 LR - 20211021 IS - 1178-2005 (Electronic) IS - 1176-9106 (Print) IS - 1176-9106 (Linking) VI - 9 DP - 2014 TI - Experience of fatigue, and its relationship to physical capacity and disease severity in men and women with COPD. PG - 17-25 LID - 10.2147/COPD.S52506 [doi] AB - INTRODUCTION: Several differences have been reported in the clinical characteristics of chronic obstructive pulmonary disease (COPD) between men and women. Differences have been found in the association between respiratory symptoms and lung function, and in the factors associated with dyspnea. This raises the question of whether there are differences between the sexes in the relationship between fatigue, the second most prevalent symptom, and the variables of physical capacity and disease severity. OBJECTIVES: To examine the experience of fatigue and its relationship to physical capacity and disease severity in men and women with COPD. METHODS: In a cross-sectional study 121 patients with COPD (54 men and 67 women), the experience of fatigue (frequency, duration, and severity) and physical capacity (lung function, 6-minute walk distance [6MWD], grip strength, and timed-stand test) were assessed. Disease severity was graded according to the Body mass index, airway Obstruction, Dyspnoea and Exercise capacity (BODE) index. Two multiple logistic regression models were tested, both of which were performed separately in men and women, to examine the association between the experience of fatigue and variables of physical capacity and the BODE index. RESULTS: Eighty-nine (73.6%) patients experienced fatigue, with similar proportions in men and women. The men with fatigue had worse physical capacity and more severe disease than did the men without fatigue: for men with and without fatigue, respectively, the percent of predicted forced expiratory volume in 1 second (FEV1) (mean [standard deviation]) was 47 (14) vs 64 (17); the 6MWD (mean [standard deviation]) was 398 (138) vs 539 (105) m; and the BODE index (median [quartile 1-3]) was 3 (2-5) vs 1 (0-1) (P<0.01). In women, only higher leg fatigue post-6MWD was seen among those experiencing fatigue compared with women without fatigue: for women with and without fatigue, respectively, leg fatigue (median [quartile 1-3]) was 4 (3-5) vs 2 (0-3) (P<0.001). The regression models showed that the 6MWD and the BODE index were associated with fatigue in both men and women, but in women, leg fatigue remained an independent associate in both models. CONCLUSION: Exercise capacity and disease severity were associated with fatigue in both men and women. In women, leg fatigue was strongly associated with fatigue, which warrants further investigation. FAU - Todt, Kristina AU - Todt K AD - Department of Social and Welfare Studies, Faculty of Health Sciences, Linkoping University, Norrkoping, Sweden ; Department of Pulmonary Medicine, University Hospital, Linkoping, Sweden. FAU - Skargren, Elisabeth AU - Skargren E AD - Department of Medicine and Health, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden. FAU - Kentson, Magnus AU - Kentson M AD - Department of Pulmonary Medicine, Ryhov Hospital, Jonkoping, Sweden. FAU - Theander, Kersti AU - Theander K AD - Department of Nursing, Faculty of Social and Life Sciences, Karlstad University, Karlstad, Sweden ; Primary Care Research Unit, County Council of Varmland, Sweden. FAU - Jakobsson, Per AU - Jakobsson P AD - Department of Pulmonary Medicine, University Hospital, Linkoping, Sweden. FAU - Unosson, Mitra AU - Unosson M AD - Department of Social and Welfare Studies, Faculty of Health Sciences, Linkoping University, Norrkoping, Sweden. LA - eng PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20131216 PL - New Zealand TA - Int J Chron Obstruct Pulmon Dis JT - International journal of chronic obstructive pulmonary disease JID - 101273481 SB - IM MH - Aged MH - Chi-Square Distribution MH - Cross-Sectional Studies MH - Exercise Test MH - *Exercise Tolerance MH - Fatigue/diagnosis/*etiology/physiopathology MH - Female MH - Forced Expiratory Volume MH - Hand Strength MH - Humans MH - Logistic Models MH - Lung/*physiopathology MH - Male MH - Middle Aged MH - Multivariate Analysis MH - Muscle Fatigue MH - Odds Ratio MH - Pulmonary Disease, Chronic Obstructive/*complications/diagnosis/physiopathology MH - Risk Factors MH - Severity of Illness Index MH - Sex Factors MH - Sweden MH - Vital Capacity PMC - PMC3869832 OTO - NOTNLM OT - chronic obstructive pulmonary disease OT - disease state OT - functional capacity OT - leg fatigue OT - sex differences OT - symptom experience EDAT- 2013/12/26 06:00 MHDA- 2014/08/26 06:00 PMCR- 2013/12/16 CRDT- 2013/12/26 06:00 PHST- 2013/12/26 06:00 [entrez] PHST- 2013/12/26 06:00 [pubmed] PHST- 2014/08/26 06:00 [medline] PHST- 2013/12/16 00:00 [pmc-release] AID - copd-9-017 [pii] AID - 10.2147/COPD.S52506 [doi] PST - ppublish SO - Int J Chron Obstruct Pulmon Dis. 2014;9:17-25. doi: 10.2147/COPD.S52506. Epub 2013 Dec 16.