PMID- 24369135
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20211021
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Print)
IS  - 1008-682X (Linking)
VI  - 16
IP  - 1
DP  - 2014 Jan-Feb
TI  - Persistent organic pollutants and male reproductive health.
PG  - 71-80
LID - 10.4103/1008-682X.122345 [doi]
AB  - Environmental contaminants such as persistent organic pollutants (POPs) are 
      man-made bioaccumulative compounds with long half-lives that are found throughout 
      the world as a result of heavy use in a variety of consumer products during the 
      twentieth century. Wildlife and animal studies have long suggested adverse 
      effects of exposure to these compounds on human reproductive health, which, 
      according to the endocrine disrupter hypothesis, are ascribed to the compounds' 
      potential to interfere with endocrine signaling, especially when exposure occurs 
      during certain phases of fetal and childhood development. An extensive number of 
      epidemiological studies have addressed the possible effects of exposure to POPs 
      on male reproductive health, but the results are conflicting. Thus far, most 
      studies have focused on investigating exposure and the different reproductive 
      health outcomes during adulthood. Some studies have addressed the potential 
      harmful effects of fetal exposure with respect to malformations at birth and/or 
      reproductive development, whereas only a few studies have been able to evaluate 
      whether intrauterine exposure to POPs has long-term consequences for male 
      reproductive health with measurable effects on semen quality markers and 
      reproductive hormone levels in adulthood. Humans are not exposed to a single 
      compound at a time, but rather, to a variety of different substances with 
      potential divergent hormonal effects. Hence, how to best analyze epidemiological 
      data on combined exposures remains a significant challenge. This review on POPs 
      will focus on current knowledge regarding the potential effects of exposure to 
      POPs during fetal and childhood life and during adulthood on male reproductive 
      health, including a critical revision of the endocrine disruption hypothesis, a 
      comment on pubertal development as part of reproductive development and a comment 
      on how to account for combined exposures in epidemiological research.
FAU - Vested, Anne
AU  - Vested A
AD  - Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University 
      Hospital, Aarhus, Denmark.
FAU - Giwercman, Aleksander
AU  - Giwercman A
FAU - Bonde, Jens Peter
AU  - Bonde JP
FAU - Toft, Gunnar
AU  - Toft G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Hydrocarbons, Halogenated)
RN  - CIW5S16655 (DDT)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Abnormalities, Drug-Induced
MH  - Adult
MH  - Animals
MH  - Child
MH  - DDT/adverse effects
MH  - Environmental Exposure/adverse effects
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Fluorocarbons/adverse effects
MH  - Humans
MH  - Hydrocarbons, Halogenated/adverse effects
MH  - Male
MH  - Polychlorinated Biphenyls/adverse effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Puberty/drug effects
MH  - Reproduction/*drug effects
MH  - Reproductive Health
MH  - Semen Analysis
MH  - Sperm Motility/drug effects
PMC - PMC3901884
EDAT- 2013/12/27 06:00
MHDA- 2014/09/03 06:00
PMCR- 2014/01/01
CRDT- 2013/12/27 06:00
PHST- 2013/12/27 06:00 [entrez]
PHST- 2013/12/27 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - AsianJAndrol_2014_16_1_71_122345 [pii]
AID - AJA-16-71 [pii]
AID - 10.4103/1008-682X.122345 [doi]
PST - ppublish
SO  - Asian J Androl. 2014 Jan-Feb;16(1):71-80. doi: 10.4103/1008-682X.122345.