PMID- 24369161
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20221207
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 34
IP  - 12
DP  - 2013 Dec
TI  - [The characteristics of frequency distribution of KIR2DL1 alleles polymorphism 
      and recognition HLA-C ligand in the Chinese Han population].
PG  - 1038-43
LID - 10.3760/cma.j.issn.0253-2727.2013.12.009 [doi]
AB  - OBJECTIVE: To find out the distributed characteristics of KIR2DL1 alleles 
      frequencies and the recognition HLA-C ligand in the Chinese Han population. 
      METHODS: The 111 patients and 116 donors from CMDP were performed the KIR2DL1 
      high-resolution typing and KIR genotyping using sequence-based testing (SBT) and 
      PCR-SSP methods. RESULTS: A total of 224 individuals with KIR2DL1 locus was 
      predominantly observed and accounted for 98.68% (224/227). There were 3 different 
      KIR2DL1 alleles, including KIR2DL1*00302, *00201 and *00401 alleles polymorphism. 
      The most common phenotype observed were KIR2DL1*00302 (84.82%, 380/448), 
      KIR2DL1*00201 (12.05%, 54/448) and KIR2DL1*00401(3.13%,14/448), present at allele 
      genotype frequencies of 61.04%,6.22% and 1.58% respectively. The allele 
      homozygotic types of KIR2DL1*00302 and KIR2DL1*00302 were the most frequent in 6 
      KIR2DL1 allele by high resolution typing. The allele heterozygous types of 
      KIR2DL1*00302 and KIR2DL1*00401 presented statistically different in haplotypes 
      A/A and B/x (P=0.001), and KIR2DL1*00401 lacked of all A/A haplotype. The 
      KIR2DL1*00302 and KIR2DL1*00201 allele had significant positive associations 
      between different KIR pairs of KIR2DS1, KIR2DL3, KIR2DS4 and KIR3DL1/S1 using 
      linkage disequilibrium analysis (P<0.01), respectively. In the receptor-ligand of 
      KIR/HLA model after allo-HSCT, KIR2DL1*00302 alleles correlated with their HLA-C2 
      group ligands. KIR2DL1*00302 and HLA-C*06:02 was the most common combination 
      ligand model, but KIR2DL1*00302 and HLA-C*01:02 was the most frequent mismatch 
      ligand model with the development of NK cell-induced alloreactivity, meanwhile 
      there was statistically significant difference of frequency distribution 
      (P<0.05). CONCLUSION: The KIR2DL1*00302 was the most frequent allele in Chinese 
      Han population. The KIR2DL1 high resolution typing would be beneficial for 
      predicting donor NK cells all activity after hematopoietic stem cell 
      transplantation and selecting suitable donors.
FAU - Wang, Miao
AU  - Wang M
AD  - The First Affiliated Hospial of Soochow University, Jiangsu Institute of 
      Hematology, Suzhou 215006, China.
FAU - He, Jun
AU  - He J
FAU - Bao, Xiao-jing
AU  - Bao XJ
FAU - Qiu, Qiao-cheng
AU  - Qiu QC
FAU - Li, Yang
AU  - Li Y
FAU - Xu, Chao
AU  - Xu C
FAU - Yuan, Xiao-ni
AU  - Yuan XN
FAU - Li, Ling-jie
AU  - Li LJ
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
RN  - 0 (HLA-C Antigens)
RN  - 0 (KIR2DL1 protein, human)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR2DL1)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-C Antigens/*genetics
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Ligands
MH  - Polymorphism, Genetic
MH  - Receptors, KIR2DL1/*genetics
EDAT- 2013/12/27 06:00
MHDA- 2015/02/20 06:00
CRDT- 2013/12/27 06:00
PHST- 2013/12/27 06:00 [entrez]
PHST- 2013/12/27 06:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
AID - 10.3760/cma.j.issn.0253-2727.2013.12.009 [doi]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2013 Dec;34(12):1038-43. doi: 
      10.3760/cma.j.issn.0253-2727.2013.12.009.