PMID- 24369486
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131226
LR  - 20220310
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2013
DP  - 2013
TI  - The efficacy and safety of traditional chinese medicine (jiang zhi granule) for 
      nonalcoholic Fatty liver: a multicenter, randomized, placebo-controlled study.
PG  - 965723
LID - 10.1155/2013/965723 [doi]
LID - 965723
AB  - Objective. To evaluate the efficacy and safety of Jiang Zhi Granule (JZG), a 
      Chinese herbal formula, in patients with nonalcoholic fatty liver (NAFL). 
      Methods. A multicenter, randomized, double-blind, placebo-controlled, parallel 
      clinical trial was conducted for 24 weeks in 224 patients with NAFL at 6 
      university-affiliated hospitals. Patients were randomized 1 : 1 to receive JZG 
      and placebo, respectively. Primary outcome was the change of liver to spleen 
      ratio (L/S ratio) over computed tomography (CT). Secondary outcomes included body 
      mass index (BMI), serum triglyceride (TG), and total cholesterol (TC) levels. 
      Results. Of all the 224 eligible patients, 221 patients were analyzed in the full 
      analysis set (FAS), 205 in the per protocol set (PPS), and 3 patients were 
      withdrawn prematurely. For FAS, JZG significantly increased L/S ratio from 0.74 +/- 
      0.21 to 0.99 +/- 0.24 compared to that from 0.79 +/- 0.18 to 0.85 +/- 0.27 in placebo 
      group (P = 0.0011). For PPS, it showed an increase of 0.26 +/- 0.23 of L/S ratio in 
      the patients on JZG versus 0.07 +/- 0.22 in those on placebo (P = 0.0003). 
      Superiority of JZG over placebo was also observed with greater reduction in BMI 
      (P < 0.05) in both FAS and PPS. No observable difference in decrease of serum TC 
      and TG was recorded (P > 0.05). There were no serious adverse events (AEs) in the 
      study process and safety indices were normal in both groups. Conclusions. The 
      Chinese herbal formula JZG was found to be superior to placebo in increasing L/S 
      ratio and reducing BMI in NAFL patients. It was also well tolerated in patients 
      and might be a safe and effective medicine for NAFL.
FAU - Pan, Jielu
AU  - Pan J
AD  - Institute of Digestive Disease, Longhua Hospital, Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200032, China.
FAU - Wang, Miao
AU  - Wang M
AD  - Institute of Digestive Disease, Longhua Hospital, Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200032, China.
FAU - Song, Haiyan
AU  - Song H
AD  - Institute of Digestive Disease, Longhua Hospital, Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200032, China.
FAU - Wang, Lin
AU  - Wang L
AD  - Department of Social Sciences, Shanghai University of Traditional Chinese 
      Medicine, Shanghai 201203, China.
FAU - Ji, Guang
AU  - Ji G
AD  - Institute of Digestive Disease, Longhua Hospital, Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200032, China ; E-Institute of Shanghai 
      Municipal Education Commission, Shanghai University of Traditional Chinese 
      Medicine, Shanghai 201203, China.
LA  - eng
PT  - Journal Article
DEP - 20131204
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3867828
EDAT- 2013/12/27 06:00
MHDA- 2013/12/27 06:01
PMCR- 2013/12/04
CRDT- 2013/12/27 06:00
PHST- 2013/06/28 00:00 [received]
PHST- 2013/10/28 00:00 [revised]
PHST- 2013/11/08 00:00 [accepted]
PHST- 2013/12/27 06:00 [entrez]
PHST- 2013/12/27 06:00 [pubmed]
PHST- 2013/12/27 06:01 [medline]
PHST- 2013/12/04 00:00 [pmc-release]
AID - 10.1155/2013/965723 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2013;2013:965723. doi: 10.1155/2013/965723. 
      Epub 2013 Dec 4.