PMID- 24369603
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 31
IP  - 8
DP  - 2013 Aug
TI  - [Determination of ribavirin and amantadine in chicken by ultra performance liquid 
      chromatography-tandem mass spectrometry].
PG  - 724-8
AB  - A method for the determination of ribavirin and amantadine in chicken has been 
      developed by ultra performance liquid chromatography-tandem mass spectrometry 
      (UPLC-MS/ MS). After extracted by 1% (volume percentage) trichloroacetic acid 
      solution-acetonitrile (1:1, v/v) and purified by a Supelco LC-SCX cartridge, the 
      samples were loaded onto an Acquity UPLC BEH Hillic column (150 mm x 2.1 mm, 1.7 
      microm) and separated with gradient elution. The electrospray was operated in the 
      positive mode and the samples were monitored by the multiple reaction monitoring 
      (MRM) mode. The limits of quantification (LOQs, S/N = 10) of ribavirin and 
      amantadine were 4.0 microg/kg. The calibration curves showed good linearity in 
      the range of 10.0 - 100.0 microg/L, and the correlation coefficients (r(2)) were 
      not lower than 0.99. When the spiked levels were 4.0, 8.0 and 20.0 microg/kg, the 
      recoveries of ribavirin and amantadine in chicken ranged from 78% to 102.5%, with 
      the relative standard deviations (RSDs) of 2.2% - 7.6%. The results indicate that 
      the method is simple, rapid, sensitive and suitable for the qualitative and 
      quantitative analyses of ribavirin and amantadine in chicken samples.
FAU - Yun, Huan
AU  - Yun H
AD  - Technology Center of Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 
      100026, China. yunh@bjciq.gov.cn
FAU - Cui, Fengyun
AU  - Cui F
AD  - Technology Center of Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 
      100026, China.
FAU - Yan, Hua
AU  - Yan H
AD  - Technology Center of Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 
      100026, China.
FAU - Liu, Xin
AU  - Liu X
AD  - Technology Center of Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 
      100026, China.
FAU - He, Yue
AU  - He Y
AD  - Technology Center of Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 
      100026, China.
FAU - Zhang, Zhaohui
AU  - Zhang Z
AD  - Technology Center of Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 
      100026, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 49717AWG6K (Ribavirin)
RN  - BF4C9Z1J53 (Amantadine)
SB  - IM
MH  - Amantadine/*analysis
MH  - Animals
MH  - *Chickens
MH  - Chromatography, High Pressure Liquid
MH  - Food Contamination/*analysis
MH  - Meat/*analysis
MH  - Ribavirin/*analysis
MH  - Tandem Mass Spectrometry
EDAT- 2013/12/29 06:00
MHDA- 2015/07/15 06:00
CRDT- 2013/12/28 06:00
PHST- 2013/12/28 06:00 [entrez]
PHST- 2013/12/29 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.3724/sp.j.1123.2013.01023 [doi]
PST - ppublish
SO  - Se Pu. 2013 Aug;31(8):724-8. doi: 10.3724/sp.j.1123.2013.01023.