PMID- 24370357
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20131227
IS  - 1001-9391 (Print)
IS  - 1001-9391 (Linking)
VI  - 31
IP  - 12
DP  - 2013 Dec
TI  - [Effect of carbon disulfide exposure during peri-implantation period on levels of 
      calcitonin and progesterone in uterus of mice].
PG  - 881-5
AB  - OBJECTIVE: To evaluate the effect of carbon disulfide (CS2) exposure during the 
      peri-implantation period on the levels of calcitonin (CT) and progesterone (P4) 
      in the uterus of pregnant mice and to investigate the mechanism of embryo loss 
      induced by CS2 exposure during the peri-implantation period. METHODS: A total of 
      168 healthy pregnant Kunming mice were randomly assigned to receive an 
      intraperitoneal injection of CS2 (631.4 mg/kg) or olive oil (control) on 
      gestational day (GD) 3, GD4, GD5, or GD6. The experiment was completed at 
      different end points (GD4, GD5, GD6, GD7, and GD9). The levels of CT and P4 in 
      the uterus were measured by enzyme-linked immunosorbent assay at each end point. 
      RESULTS: The numbers of implanted embryos in GD3, GD4, GD5, and GD6 exposure 
      groups significantly decreased by 42.85%, 63.74%, 60.45%, and 47.26%, 
      respectively,compared with those in control group (P < 0.01). The GD3, GD4, GD5, 
      and GD6 exposure groups had significantly decreased CT levels at each end point 
      (P < 0.05), and the GD3, GD4, and GD5 exposure groups had significantly decreased 
      P4 levels (P < 0.05). In the GD3, GD4, GD5, and GD6 exposure groups, the number 
      of implanted embryos was positively related with the levels of CT and P4 
      expressed in the uterus (r = 0.670, P < 0.01; r = 0.632, P < 0.01); the 
      expression level of CT was positively related with that of P4 in the uterus of 
      pregnant mice (r = 0.325, P < 0.01). CONCLUSION: Exposure to CS2 during the 
      peri-implantation period can reduce the expression levels of CT and P4 in the 
      uterus of pregnant mice, which might be one of the molecular mechanisms of embryo 
      loss induced by CS2 exposure.
FAU - Yang, Liu
AU  - Yang L
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Shandong University, Jinan 250012, China.
FAU - Wang, Zhi-ping
AU  - Wang ZP
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Shandong University, Jinan 250012, China. E-mail: zhipingw@sdu.edu.cn.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
JT  - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng 
      zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
JID - 8410840
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 9007-12-9 (Calcitonin)
RN  - S54S8B99E8 (Carbon Disulfide)
SB  - IM
MH  - Animals
MH  - Calcitonin/*metabolism
MH  - Carbon Disulfide/*adverse effects
MH  - Embryo Implantation
MH  - Female
MH  - Maternal Exposure/*adverse effects
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Pregnancy
MH  - Progesterone/*metabolism
MH  - Uterus/drug effects/*metabolism
EDAT- 2013/12/29 06:00
MHDA- 2015/01/06 06:00
CRDT- 2013/12/28 06:00
PHST- 2013/12/28 06:00 [entrez]
PHST- 2013/12/29 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
PST - ppublish
SO  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2013 Dec;31(12):881-5.