PMID- 24370447
OWN - NLM
STAT- MEDLINE
DCOM- 20141114
LR  - 20220129
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Print)
IS  - 0939-4753 (Linking)
VI  - 24
IP  - 3
DP  - 2014 Mar
TI  - Dietary total antioxidant capacity is related to glucose tolerance in older 
      people: the Hertfordshire Cohort Study.
PG  - 301-8
LID - S0939-4753(13)00176-2 [pii]
LID - 10.1016/j.numecd.2013.08.001 [doi]
AB  - BACKGROUND AND AIMS: Dietary antioxidants may play a protective role in the 
      aetiology of type 2 diabetes. However, observational studies that examine the 
      relationship between the antioxidant capacity of the diet and glucose metabolism 
      are limited, particularly in older people. We aimed to examine the relationships 
      between dietary total antioxidant capacity (TAC) and markers of glucose 
      metabolism among 1441 men and 1253 women aged 59-73 years who participated in the 
      Hertfordshire Cohort Study, UK. METHODS AND RESULTS: Diet was assessed by food 
      frequency questionnaire. Dietary TAC was estimated using published databases of 
      TAC measured by four different assays: oxygen radical absorbance capacity (ORAC), 
      ferric-reducing ability of plasma (FRAP), total radical-trapping antioxidant 
      parameter (TRAP) and trolox equivalent antioxidant capacity (TEAC). Fasting and 
      120-min plasma glucose and insulin concentrations were measured during a standard 
      75-g oral glucose tolerance test. In men, dietary TAC estimated by all four 
      assays was inversely associated with fasting insulin concentration and 
      homoeostasis model assessment of insulin resistance (HOMA-IR); with the exception 
      of ORAC, dietary TAC was also inversely related to 120-min glucose concentration. 
      There were no associations with fasting glucose or 120-min insulin 
      concentrations. In women, with the exception of the association between ORAC and 
      120-min insulin concentration, dietary TAC estimated by all assays showed 
      consistent inverse associations with fasting and 120-min glucose and insulin 
      concentrations and HOMA-IR. These associations were more marked among women with 
      BMI >/= 30 kg/m(2). CONCLUSION: These findings suggest dietary TAC may have 
      important protective effects on glucose tolerance, especially in older obese 
      women.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Okubo, H
AU  - Okubo H
AD  - MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; 
      Department of Social and Preventive Epidemiology, Graduate School of Medicine, 
      The University of Tokyo, Tokyo, Japan.
FAU - Syddall, H E
AU  - Syddall HE
AD  - MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
FAU - Phillips, D I W
AU  - Phillips DI
AD  - MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
FAU - Sayer, A A
AU  - Sayer AA
AD  - MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
FAU - Dennison, E M
AU  - Dennison EM
AD  - MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
FAU - Cooper, C
AU  - Cooper C
AD  - MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
FAU - Robinson, S M
AU  - Robinson SM
AD  - MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. 
      Electronic address: smr@mrc.soton.ac.uk.
CN  - Hertfordshire Cohort Study Group
LA  - eng
GR  - MC_UP_A620_1015/MRC_/Medical Research Council/United Kingdom
GR  - MC_U147585819/MRC_/Medical Research Council/United Kingdom
GR  - MC_UU_12011/2/MRC_/Medical Research Council/United Kingdom
GR  - MC_UU_12011/1/MRC_/Medical Research Council/United Kingdom
GR  - MC_UP_A620_1014/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131024
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Aged
MH  - Antioxidants/*administration & dosage
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Body Weight
MH  - Diabetes Mellitus, Type 2
MH  - Diet
MH  - Fasting
MH  - Female
MH  - Glucose Intolerance/*blood
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood
MH  - Life Style
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Motor Activity
MH  - Nutrition Assessment
MH  - Prospective Studies
MH  - Surveys and Questionnaires
MH  - United Kingdom
PMC - PMC4112602
MID - EMS57084
OID - NLM: EMS57084
OTO - NOTNLM
OT  - Diet
OT  - Epidemiology
OT  - Glucose tolerance
OT  - Total antioxidant capacity
EDAT- 2013/12/29 06:00
MHDA- 2014/11/15 06:00
PMCR- 2014/09/01
CRDT- 2013/12/28 06:00
PHST- 2013/03/28 00:00 [received]
PHST- 2013/07/30 00:00 [revised]
PHST- 2013/08/05 00:00 [accepted]
PHST- 2013/12/28 06:00 [entrez]
PHST- 2013/12/29 06:00 [pubmed]
PHST- 2014/11/15 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - S0939-4753(13)00176-2 [pii]
AID - 10.1016/j.numecd.2013.08.001 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2014 Mar;24(3):301-8. doi: 
      10.1016/j.numecd.2013.08.001. Epub 2013 Oct 24.