PMID- 24370891
OWN - NLM
STAT- MEDLINE
DCOM- 20150408
LR  - 20140818
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Linking)
VI  - 19
IP  - 8
DP  - 2014 Aug
TI  - A potential role for GPR55 in the regulation of energy homeostasis.
PG  - 1145-51
LID - S1359-6446(13)00423-6 [pii]
LID - 10.1016/j.drudis.2013.12.005 [doi]
AB  - G protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor that is 
      expressed in several tissues involved in regulating energy homeostasis, including 
      the hypothalamus, gastrointestinal tract, pancreas, liver, white adipose and 
      skeletal muscle. GPR55 has been shown to have a role in cancer and 
      gastrointestinal inflammation, as well as in obesity and type 2 diabetes mellitus 
      (T2DM). Despite this, the (patho)physiological role of GPR55 in cell dysfunction 
      is still poorly understood, largely because of the limited identification of 
      downstream signalling targets. Nonetheless, research has suggested that GPR55 
      modulation would be a useful pharmacological target in metabolically active 
      tissues to improve treatment of diseases such as obesity and T2DM. Further 
      research is essential to gain a better understanding of the role that this 
      receptor might have in these and other pathophysiological conditions.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Simcocks, Anna C
AU  - Simcocks AC
AD  - Centre for Chronic Disease Prevention and Management, College of Health and 
      Biomedicine, Victoria University, Melbourne 8001, VIC, Australia.
FAU - O'Keefe, Lannie
AU  - O'Keefe L
AD  - Centre for Chronic Disease Prevention and Management, College of Health and 
      Biomedicine, Victoria University, Melbourne 8001, VIC, Australia.
FAU - Jenkin, Kayte A
AU  - Jenkin KA
AD  - Centre for Chronic Disease Prevention and Management, College of Health and 
      Biomedicine, Victoria University, Melbourne 8001, VIC, Australia.
FAU - Mathai, Michael L
AU  - Mathai ML
AD  - Centre for Chronic Disease Prevention and Management, College of Health and 
      Biomedicine, Victoria University, Melbourne 8001, VIC, Australia; The Florey 
      Institute for Neuroscience and Mental Health, The University of Melbourne, 
      Parkville, VIC, Australia.
FAU - Hryciw, Deanne H
AU  - Hryciw DH
AD  - Department of Physiology, The University of Melbourne, Melbourne 3010, VIC, 
      Australia.
FAU - McAinch, Andrew J
AU  - McAinch AJ
AD  - Centre for Chronic Disease Prevention and Management, College of Health and 
      Biomedicine, Victoria University, Melbourne 8001, VIC, Australia. Electronic 
      address: andrew.mcainch@vu.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131224
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Energy Metabolism/*physiology
MH  - Homeostasis/*physiology
MH  - Humans
MH  - Receptors, G-Protein-Coupled/*metabolism
EDAT- 2013/12/29 06:00
MHDA- 2015/04/09 06:00
CRDT- 2013/12/28 06:00
PHST- 2013/08/22 00:00 [received]
PHST- 2013/10/31 00:00 [revised]
PHST- 2013/12/11 00:00 [accepted]
PHST- 2013/12/28 06:00 [entrez]
PHST- 2013/12/29 06:00 [pubmed]
PHST- 2015/04/09 06:00 [medline]
AID - S1359-6446(13)00423-6 [pii]
AID - 10.1016/j.drudis.2013.12.005 [doi]
PST - ppublish
SO  - Drug Discov Today. 2014 Aug;19(8):1145-51. doi: 10.1016/j.drudis.2013.12.005. 
      Epub 2013 Dec 24.