PMID- 24371386
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131227
LR  - 20211021
IS  - 1013-9087 (Print)
IS  - 2005-3894 (Electronic)
IS  - 1013-9087 (Linking)
VI  - 25
IP  - 4
DP  - 2013 Nov
TI  - Staphylococcus aureus Colonization in Acute and Chronic Skin Lesions of Patients 
      with Atopic Dermatitis.
PG  - 410-6
LID - 10.5021/ad.2013.25.4.410 [doi]
AB  - BACKGROUND: Staphylococcus aureus (SA) has peculiar abilities to colonize the 
      skin in atopic dermatitis (AD) patients. OBJECTIVE: We sought to determine the 
      colonization rates of SA in acute and chronic skin lesions of AD patients, to 
      find any difference in colonization rates according to age and to find the 
      influences of total immunoglobulin E (IgE) and eosinophil counts to the 
      colonization of SA. METHODS: We evaluated the total IgE level and eosinophil 
      counts, and cultured SA from the skin lesions of 687 AD patients (131 acute and 
      556 chronic skin lesions) and 247 control urticaria patients (July 2009 to 
      November 2010; Samsung Medical Center Dermatology Clinic, Seoul, Korea). RESULTS: 
      The SA colonization rates were 74%, 38% and 3% in acute, chronic skin lesions and 
      control skin, respectively, and they were increased with age in AD patients. The 
      colonization rate in chronic skin lesions was higher in the high IgE/eosinophilia 
      groups as compared to the normal IgE/eosinophil groups. CONCLUSION: The SA 
      colonization rate was higher in AD patients and especially in acute lesions, and 
      had a tendency to increase with age. As the colonization rates were only higher 
      in the high IgE/eosinophilia groups of chronic skin lesions, we suggested that SA 
      may invade the skin through barrier defects in acute skin lesions, but the 
      colonization in chronic lesions may be orchestrated through many different 
      factors.
FAU - Park, Hae-Young
AU  - Park HY
AD  - Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Korea.
FAU - Kim, Cho-Rok
AU  - Kim CR
AD  - Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Korea.
FAU - Huh, Ik-Soo
AU  - Huh IS
AD  - Department of Statistics, Medical Research Center, Seoul National University, 
      Seoul, Korea.
FAU - Jung, Mi-Young
AU  - Jung MY
AD  - Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Korea.
FAU - Seo, Eun-Young
AU  - Seo EY
AD  - Institute of Dermatological Science, Medical Research Center, Seoul National 
      University, Seoul, Korea.
FAU - Park, Ji-Hye
AU  - Park JH
AD  - Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Korea.
FAU - Lee, Dong-Youn
AU  - Lee DY
AD  - Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Korea.
FAU - Yang, Jun-Mo
AU  - Yang JM
AD  - Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20131130
PL  - Korea (South)
TA  - Ann Dermatol
JT  - Annals of dermatology
JID - 8916577
PMC - PMC3870207
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Colonization rate
OT  - Eosinophil counts
OT  - Serum total IgE
OT  - Staphylococcus aureus
EDAT- 2013/12/29 06:00
MHDA- 2013/12/29 06:01
PMCR- 2013/11/01
CRDT- 2013/12/28 06:00
PHST- 2012/04/27 00:00 [received]
PHST- 2012/08/03 00:00 [revised]
PHST- 2012/09/01 00:00 [accepted]
PHST- 2013/12/28 06:00 [entrez]
PHST- 2013/12/29 06:00 [pubmed]
PHST- 2013/12/29 06:01 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - 10.5021/ad.2013.25.4.410 [doi]
PST - ppublish
SO  - Ann Dermatol. 2013 Nov;25(4):410-6. doi: 10.5021/ad.2013.25.4.410. Epub 2013 Nov 
      30.