PMID- 24371798
OWN - NLM
STAT- MEDLINE
DCOM- 20150519
LR  - 20220330
IS  - 2213-1582 (Print)
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 4
DP  - 2014
TI  - The neural basis of theory of mind and its relationship to social functioning and 
      social anhedonia in individuals with schizophrenia.
PG  - 154-63
LID - 10.1016/j.nicl.2013.11.006 [doi]
AB  - Theory of mind (ToM), the ability to attribute and reason about the mental states 
      of others, is a strong determinant of social functioning among individuals with 
      schizophrenia. Identifying the neural bases of ToM and their relationship to 
      social functioning may elucidate functionally relevant neurobiological targets 
      for intervention. ToM ability may additionally account for other social phenomena 
      that affect social functioning, such as social anhedonia (SocAnh). Given recent 
      research in schizophrenia demonstrating improved neural functioning in response 
      to increased use of cognitive skills, it is possible that SocAnh, which decreases 
      one's opportunity to engage in ToM, could compromise social functioning through 
      its deleterious effect on ToM-related neural circuitry. Here, twenty individuals 
      with schizophrenia and 18 healthy controls underwent fMRI while performing the 
      False-Belief Task. Aspects of social functioning were assessed using multiple 
      methods including self-report (Interpersonal Reactivity Index, Social Adjustment 
      Scale), clinician-ratings (Global Functioning Social Scale), and 
      performance-based tasks (MSCEIT-Managing Emotions). SocAnh was measured with the 
      Revised Social Anhedonia Scale. Region-of-interest and whole-brain analyses 
      revealed reduced recruitment of medial prefrontal cortex (MPFC) for ToM in 
      individuals with schizophrenia. Across all participants, activity in this region 
      correlated with most social variables. Mediation analysis revealed that neural 
      activity for ToM in MPFC accounted for the relationship between SocAnh and social 
      functioning. These findings demonstrate that reduced recruitment of MPFC for ToM 
      is an important neurobiological determinant of social functioning. Furthermore, 
      SocAhn may affect social functioning through its impact on ToM-related neural 
      circuitry. Together, these findings suggest ToM ability as an important locus for 
      intervention.
FAU - Dodell-Feder, David
AU  - Dodell-Feder D
AD  - Department of Psychology, Harvard University, Cambridge, MA 02138, USA.
FAU - Tully, Laura M
AU  - Tully LM
AD  - Department of Psychology, Harvard University, Cambridge, MA 02138, USA.
FAU - Lincoln, Sarah Hope
AU  - Lincoln SH
AD  - Department of Psychology, Harvard University, Cambridge, MA 02138, USA.
FAU - Hooker, Christine I
AU  - Hooker CI
AD  - Department of Psychology, Harvard University, Cambridge, MA 02138, USA.
LA  - eng
GR  - R90 DA023427/DA/NIDA NIH HHS/United States
GR  - T90 DA022759/DA/NIDA NIH HHS/United States
GR  - T90DA022759/DA/NIDA NIH HHS/United States
GR  - R90DA023427/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131127
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Anhedonia/*physiology
MH  - Brain/blood supply/pathology
MH  - Case-Control Studies
MH  - Cognition Disorders/*etiology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Oxygen/blood
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*complications/*pathology
MH  - *Schizophrenic Psychology
MH  - Self Report
MH  - *Social Perception
MH  - Statistics as Topic
MH  - Theory of Mind/*physiology
MH  - Young Adult
PMC - PMC3871293
OTO - NOTNLM
OT  - Schizophrenia
OT  - Social anhedonia
OT  - Social functioning
OT  - Theory of mind
OT  - fMRI
EDAT- 2013/12/29 06:00
MHDA- 2013/12/29 06:01
PMCR- 2013/11/27
CRDT- 2013/12/28 06:00
PHST- 2013/09/18 00:00 [received]
PHST- 2013/11/16 00:00 [revised]
PHST- 2013/11/18 00:00 [accepted]
PHST- 2013/12/28 06:00 [entrez]
PHST- 2013/12/29 06:00 [pubmed]
PHST- 2013/12/29 06:01 [medline]
PHST- 2013/11/27 00:00 [pmc-release]
AID - S2213-1582(13)00154-X [pii]
AID - 10.1016/j.nicl.2013.11.006 [doi]
PST - epublish
SO  - Neuroimage Clin. 2013 Nov 27;4:154-63. doi: 10.1016/j.nicl.2013.11.006. 
      eCollection 2014.