PMID- 24372216
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20190823
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 21
IP  - 19
DP  - 2014
TI  - Role of connexins and pannexins in ischemic stroke.
PG  - 2165-82
AB  - Synaptic plasticity requires careful synchronization and coordination of neurons 
      and glial cells via various mechanisms of intercellular communication. Among 
      them, are those mediated by i) connexin gap junction channels (GJCs), ii) 
      connexin hemichannels and iii) pannexin channels. Whereas GJCs directly 
      communicate the cytoplasm of contacting cells and coordinate electric and 
      metabolic activities, connexin hemichannels and pannexin channels serve as 
      diffusional pathways for ions and small molecules between the intra- and 
      extracellular compartments. A growing body of evidence has revealed that 
      intercellular communication could be critical in the spread of protective and/or 
      deleterious signals during stroke. Here, we review current findings on the 
      regulation of connexin- and pannexin-based channels in ischemic stroke and how 
      they contribute to cell damage observed in pathology. Depending on intensity of 
      the ischemic event, brain region and connexin subtype expressed, GJCs may provide 
      proper diffusion of energy metabolites and dissipation of toxic substances, 
      whereas, in other circumstances, they could increase damage by spreading toxic 
      molecules. Alternatively, connexin hemichannel and pannexin channel opening may 
      favor the release of neurotoxic substances (e.g., glutamate), but in other cases, 
      they may confer neuroprotection against an ischemic episode by the phenomenon of 
      ischemic preconditioning. Development of new drug modulators using in silico 
      devices for connexin and pannexin-based channels will be crucial for future 
      therapies against stroke.
FAU - Orellana, J A
AU  - Orellana JA
FAU - Avendano, B C
AU  - Avendano BC
FAU - Montero, T D
AU  - Montero TD
AD  - Departamento de Neurologia, Escuela de Medicina, Pontificia Universidad Catolica 
      de Chile, Marcoleta 391, Santiago, Chile. jaorella@uc.cl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Connexins)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/*metabolism
MH  - Connexins/*metabolism
MH  - Gap Junctions/metabolism
MH  - Humans
MH  - Nerve Tissue Proteins/*metabolism
MH  - Stroke/*metabolism
EDAT- 2014/01/01 06:00
MHDA- 2015/01/13 06:00
CRDT- 2013/12/31 06:00
PHST- 2013/04/22 00:00 [received]
PHST- 2013/06/04 00:00 [revised]
PHST- 2013/06/05 00:00 [accepted]
PHST- 2013/12/31 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - CMC-EPUB-58352 [pii]
AID - 10.2174/0929867321666131228191714 [doi]
PST - ppublish
SO  - Curr Med Chem. 2014;21(19):2165-82. doi: 10.2174/0929867321666131228191714.