PMID- 24373377
OWN - NLM
STAT- MEDLINE
DCOM- 20150605
LR  - 20161125
IS  - 1747-0803 (Electronic)
IS  - 1747-079X (Linking)
VI  - 9
IP  - 5
DP  - 2014 Sep-Oct
TI  - Value of speckle-tracking echocardiography and MRI-based feature tracking 
      analysis in adult patients after Fontan-type palliation.
PG  - 397-406
LID - 10.1111/chd.12156 [doi]
AB  - BACKGROUND: Patients are commonly affected by ventricular dysfunction and heart 
      failure after Fontan palliation. Reliable quantification of ventricular function 
      is of interest but hampered by complex ventricular anatomy and physiology. 
      OBJECTIVES: We aimed to assess myocardial function using a novel cardiac magnetic 
      resonance imaging (CMR)-based feature-tracking (FT) technique and to study its 
      clinical utility in Fontan patients. METHODS: Retrospective study in consecutive 
      patients attending our service. RESULTS: We included 15 adult Fontan patients 
      (age 27 +/- 7 years) who underwent a standardized transthoracic echocardiographic 
      investigation (TTE) with measurement of global strain using speckle tracking. 
      Thirteen patients also underwent CMR, with assessment of myocardial deformation 
      by FT, providing longitudinal and circumferential global strain for the single 
      ventricle. The value of TTE-based strain measurements was limited by the fact 
      that in 63% of patients at least one myocardial segment could not be adequately 
      quantified due to limited acoustic windows. In contrast, CMR allowed for a 
      complete visualization of all wall segments. Not surprisingly, there was poor 
      agreement between the techniques but good or moderate interobserver variability 
      for FT (coefficients of variability 6.6% and 14.3% for circumferential and 
      longitudinal strain). Unlike ejection fraction, FT parameters correlated 
      significantly with age at Fontan completion, New York Heart Association (NYHA) 
      class, and peak oxygen uptake on cardiopulmonary exercise testing. CONCLUSIONS: 
      Assessment of myocardial function using CMR cine-based feature tracking is 
      feasible in Fontan patients. Unlike echocardiographic techniques, FT is 
      independent of inadequate acoustic windows and FT measurements relate to clinical 
      parameters, suggesting that this approach could have clinical relevance in 
      future.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Schmidt, Renate
AU  - Schmidt R
AD  - Adult Congenital and Valvular Heart Disease Center, Department of Cardiology and 
      Angiology, University Hospital of Munster, Munster, Germany.
FAU - Orwat, Stefan
AU  - Orwat S
FAU - Kempny, Aleksander
AU  - Kempny A
FAU - Schuler, Pia
AU  - Schuler P
FAU - Radke, Robert
AU  - Radke R
FAU - Kahr, Peter C
AU  - Kahr PC
FAU - Hellige, Antje
AU  - Hellige A
FAU - Baumgartner, Helmut
AU  - Baumgartner H
FAU - Diller, Gerhard-Paul
AU  - Diller GP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131224
PL  - United States
TA  - Congenit Heart Dis
JT  - Congenital heart disease
JID - 101256510
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - *Echocardiography
MH  - Exercise Test
MH  - Feasibility Studies
MH  - Fontan Procedure/*adverse effects
MH  - Germany
MH  - Heart Defects, Congenital/diagnosis/physiopathology/*surgery
MH  - Heart Failure/*diagnosis/diagnostic imaging/etiology/physiopathology
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Myocardial Contraction
MH  - Observer Variation
MH  - Palliative Care
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ventricular Dysfunction/*diagnosis/diagnostic imaging/etiology/physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Cardiac Magnetic Resonance Imaging
OT  - Echocardiography
OT  - Feature Tracking
OT  - Fontan
OT  - Speckle Tracking
EDAT- 2014/01/01 06:00
MHDA- 2015/06/06 06:00
CRDT- 2013/12/31 06:00
PHST- 2013/11/24 00:00 [accepted]
PHST- 2013/12/31 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2015/06/06 06:00 [medline]
AID - 10.1111/chd.12156 [doi]
PST - ppublish
SO  - Congenit Heart Dis. 2014 Sep-Oct;9(5):397-406. doi: 10.1111/chd.12156. Epub 2013 
      Dec 24.