PMID- 24373952
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20181202
IS  - 1527-3288 (Electronic)
IS  - 0147-9563 (Linking)
VI  - 43
IP  - 2
DP  - 2014 Mar-Apr
TI  - Full recovery after severe serotonin syndrome, severe rhabdomyolysis, multi-organ 
      failure and disseminated intravascular coagulopathy from MDMA.
PG  - 117-9
LID - S0147-9563(13)00410-X [pii]
LID - 10.1016/j.hrtlng.2013.11.009 [doi]
AB  - 3, 4-methylenedioxymethamphetamine (MDMA), popularly known as "ecstasy" is a 
      synthetic, psychoactive drug used recreationally for its euphoric and "energy 
      increasing" effects. MDMA has been linked to several severe adverse effects 
      including the development of serotonin syndrome and sudden death. Individuals of 
      Asian descent have been shown to have a predisposition for these severe adverse 
      effects. We present a case of a young Asian-American male who following MDMA 
      ingestion presented with severe rhabdomyolysis (CK 130,350 U/L), multiple organ 
      failure and severe serotonin syndrome with one of the highest recorded 
      temperatures '108.9  degrees F (42.7  degrees C)' in a survivor of severe serotonin syndrome. The 
      patient initially received supportive care including ventilatory support; he 
      eventually needed hemodialysis, but went on to make a full recovery within 3 
      weeks. This case shows and emphasizes the importance of 'aggressive' supportive 
      care on patient prognosis particularly for patients on the extreme end of the 
      serotonin syndrome.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Davies, O
AU  - Davies O
AD  - Internal Medicine Department, Columbia University at Harlem Hospital Center, 506 
      Lenox Avenue, MLK 14-106, New York, NY 10037, USA. Electronic address: 
      od2178@columbia.edu.
FAU - Batajoo-Shrestha, B
AU  - Batajoo-Shrestha B
AD  - Internal Medicine Department, Columbia University at Harlem Hospital Center, 506 
      Lenox Avenue, MLK 14-106, New York, NY 10037, USA.
FAU - Sosa-Popoteur, J
AU  - Sosa-Popoteur J
AD  - Internal Medicine Department, Columbia University at Harlem Hospital Center, 506 
      Lenox Avenue, MLK 14-106, New York, NY 10037, USA.
FAU - Olibrice, M
AU  - Olibrice M
AD  - Pulmonary and Critical Care Medicine Department, Columbia University at Harlem 
      Hospital Center, 506 Lenox Avenue, MLK 14-108, New York, NY 10037, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20131226
PL  - United States
TA  - Heart Lung
JT  - Heart & lung : the journal of critical care
JID - 0330057
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Disseminated Intravascular Coagulation/*chemically induced
MH  - Hallucinogens/*adverse effects
MH  - Humans
MH  - Male
MH  - Multiple Organ Failure/*chemically induced
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Renal Dialysis
MH  - Rhabdomyolysis/*chemically induced
MH  - Serotonin Syndrome/*chemically induced/therapy
MH  - Young Adult
OTO - NOTNLM
OT  - Ecstasy
OT  - Hyperthermia
OT  - MDMA
OT  - Serotonin
OT  - Toxicity
EDAT- 2014/01/01 06:00
MHDA- 2014/04/25 06:00
CRDT- 2013/12/31 06:00
PHST- 2013/07/11 00:00 [received]
PHST- 2013/10/21 00:00 [revised]
PHST- 2013/11/27 00:00 [accepted]
PHST- 2013/12/31 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
AID - S0147-9563(13)00410-X [pii]
AID - 10.1016/j.hrtlng.2013.11.009 [doi]
PST - ppublish
SO  - Heart Lung. 2014 Mar-Apr;43(2):117-9. doi: 10.1016/j.hrtlng.2013.11.009. Epub 
      2013 Dec 26.