PMID- 24374257 OWN - NLM STAT- MEDLINE DCOM- 20141010 LR - 20220331 IS - 1873-474X (Electronic) IS - 0736-5748 (Linking) VI - 33 DP - 2014 Apr TI - Preeclampsia alters milk neurotrophins and long chain polyunsaturated fatty acids. PG - 115-21 LID - S0736-5748(13)00180-9 [pii] LID - 10.1016/j.ijdevneu.2013.12.007 [doi] AB - OBJECTIVE: To examine the levels of breast milk neurotrophins 1.5, 3.5, and 6 months of lactation and long chain polyunsaturated fatty acids (LCPUFA) at day 3, 1.5, 2.5, 3.5 and 6 months of lactation in mothers with preeclampsia and compare them with normotensive women. Their associations with growth parameters in children are also examined. METHODS: Women with preeclampsia (n=101) and normotensive women (n=144) with singleton pregnancies were recruited for this study. Milk samples were collected and anthropometry was recorded at the first 6 months. The LCPUFA composition of milk samples was analyzed by using gas chromatography at all time points and neurotrophins were analyzed at 1.5, 3.5 and 6 months by Emax Immuno Assay System using Promega kits. RESULTS: Milk DHA levels were higher at day 3 (9.5%), and 1.5 (23%) and 3.5 (40%) months in mothers with preeclampsia as compared to controls. Milk nerve growth factor (NGF) levels were lower in preeclampsia group as compared to control group at 1.5 (20%) and 3.5 months (27.7%). Milk brain derived neurotrophic factor (BDNF) levels were lower at 1.5 months (10.5%) in the preeclampsia group as compared to control group. CONCLUSION: The present study suggests that there is a differential regulation of DHA and neurotrophins in breast milk in preeclampsia and are associated with growth parameters of children. Future studies should explore the associations between milk LCPUFA, neurotrophins with neurodevelopment in children. CI - Copyright (c) 2014 ISDN. Published by Elsevier Ltd. All rights reserved. FAU - Dangat, Kamini AU - Dangat K AD - Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, India. FAU - Kilari, Anitha AU - Kilari A AD - Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, India. FAU - Mehendale, Savita AU - Mehendale S AD - Department of Obstetrics and Gynecology, Bharati Medical College and Hospital, Bharati Vidyapeeth University, Pune 411043, India. FAU - Lalwani, Sanjay AU - Lalwani S AD - Department of Pediatrics, Bharati Medical College and Hospital, Bharati Vidyapeeth University, Pune 411043, India. FAU - Joshi, Sadhana AU - Joshi S AD - Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, India. Electronic address: srjoshi62@gmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20131225 PL - United States TA - Int J Dev Neurosci JT - International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience JID - 8401784 RN - 0 (Fatty Acids, Unsaturated) RN - 0 (Nerve Growth Factors) SB - IM MH - Adult MH - Fatty Acids, Unsaturated/*metabolism MH - Female MH - Humans MH - Lactation/metabolism MH - Longitudinal Studies MH - Male MH - Milk, Human/*metabolism MH - Nerve Growth Factors/*metabolism MH - Pre-Eclampsia/*metabolism MH - Pregnancy MH - Retrospective Studies MH - Young Adult OTO - NOTNLM OT - Anthropometry OT - BDNF OT - DHA OT - Lactation OT - NGF EDAT- 2014/01/01 06:00 MHDA- 2014/10/11 06:00 CRDT- 2013/12/31 06:00 PHST- 2013/09/11 00:00 [received] PHST- 2013/12/06 00:00 [revised] PHST- 2013/12/17 00:00 [accepted] PHST- 2013/12/31 06:00 [entrez] PHST- 2014/01/01 06:00 [pubmed] PHST- 2014/10/11 06:00 [medline] AID - S0736-5748(13)00180-9 [pii] AID - 10.1016/j.ijdevneu.2013.12.007 [doi] PST - ppublish SO - Int J Dev Neurosci. 2014 Apr;33:115-21. doi: 10.1016/j.ijdevneu.2013.12.007. Epub 2013 Dec 25.