PMID- 24374887
OWN - NLM
STAT- MEDLINE
DCOM- 20141209
LR  - 20211021
IS  - 1567-2387 (Electronic)
IS  - 1567-2379 (Linking)
VI  - 45
IP  - 3
DP  - 2014 Jun
TI  - Expression of full-length and truncated trkB in human striatum and substantia 
      nigra neurons: implications for Parkinson's disease.
PG  - 349-61
LID - 10.1007/s10735-013-9562-z [doi]
AB  - Brain derived neurotrophic factor (BDNF) is a potent mediator of cell survival 
      and differentiation and can reverse neuronal injury associated with Parkinson's 
      disease (PD). Tropomyosin receptor kinase B (trkB) is the high affinity receptor 
      for BDNF. There are two major trkB isoforms, the full-length receptor 
      (trkB.tk(+)) and the truncated receptor (trkB.t1), that mediate the diverse, 
      region specific functions of BDNF. Both trkB isoforms are widely distributed 
      throughout the brain, but the isoform specific distribution of trkB.t1 and 
      trkB.tk(+) to human neurons is not well characterized. Therefore, we report the 
      regional and neuronal distribution of trkB.tk(+) and trkB.t1 in the striatum and 
      substantia nigra pars compacta (SNpc) of human autopsy tissues from control and 
      PD cases. In both PD and control tissues, we found abundant, punctate 
      distribution of trkB.tk(+) and trkB.t1 proteins in striatum and SNpc neurons. In 
      PD, trkB.tk(+) is decreased in striatal neurites, increased in striatal somata, 
      decreased in SNpc somata and dendrites, and increased in SNpc axons. TrkB.t1 is 
      increased in striatal somata, decreased in striatal axons, and increased in SNpc 
      distal dendrites. We believe changes in trkB isoform distribution and expression 
      levels may be markers of pathology and affect the neuronal response to BDNF.
FAU - Fenner, Mark E
AU  - Fenner ME
AD  - , Forty Fort, PA, 18704, USA.
FAU - Achim, Cristian L
AU  - Achim CL
FAU - Fenner, Barbara Murray
AU  - Fenner BM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131229
PL  - Netherlands
TA  - J Mol Histol
JT  - Journal of molecular histology
JID - 101193653
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Protein Isoforms)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (tropomyosin-related kinase-B, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Case-Control Studies
MH  - Corpus Striatum/*metabolism
MH  - Gene Expression
MH  - Humans
MH  - Immunohistochemistry
MH  - Intracellular Space/metabolism
MH  - Male
MH  - Membrane Glycoproteins
MH  - Middle Aged
MH  - Neurons/metabolism
MH  - Parkinson Disease/genetics/metabolism
MH  - Protein Isoforms
MH  - Protein Kinases/genetics/*metabolism
MH  - Protein Transport
MH  - Protein-Tyrosine Kinases
MH  - Receptor, trkB
MH  - Substantia Nigra/*metabolism
EDAT- 2014/01/01 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/12/31 06:00
PHST- 2013/09/24 00:00 [received]
PHST- 2013/12/17 00:00 [accepted]
PHST- 2013/12/31 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1007/s10735-013-9562-z [doi]
PST - ppublish
SO  - J Mol Histol. 2014 Jun;45(3):349-61. doi: 10.1007/s10735-013-9562-z. Epub 2013 
      Dec 29.