PMID- 2437498
OWN - NLM
STAT- MEDLINE
DCOM- 19870528
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 75
IP  - 1
DP  - 1987 Mar 20
TI  - Central galanin stimulates pituitary prolactin secretion in rats: possible 
      involvement of hypothalamic vasoactive intestinal polypeptide.
PG  - 49-54
AB  - The effect of galanin, a newly identified neuropeptide, on pituitary prolactin 
      (PRL) secretion was examined in the rat. Intracerebroventricular (i.c.v.) 
      injection of all 5 doses of galanin (0.4, 1, 2, 5 and 10 micrograms/rat) raised 
      plasma PRL levels in urethane-anesthetized rats. Galanin injection (2 
      micrograms/rat, i.c.v.) also increased plasma PRL levels in conscious rats. The 
      intermediate dose of galanin (2 micrograms/rat, i.c.v.) produced a greater 
      response in plasma PRL levels than either smaller or larger doses of galanin. 
      Intravenous injection of galanin did not affect plasma PRL levels. Passive 
      immunization with specific anti-vasoactive intestinal polypeptide (VIP) rabbit 
      serum suppressed plasma PRL response to galanin (2 micrograms/rat, i.c.v.) in 
      anesthetized rats. These findings indicate that central galanin has a stimulatory 
      role in pituitary PRL secretion via the hypothalamus in the rat and that VIP may 
      be involved in rat PRL release induced by galanin.
FAU - Koshiyama, H
AU  - Koshiyama H
FAU - Kato, Y
AU  - Kato Y
FAU - Inoue, T
AU  - Inoue T
FAU - Murakami, Y
AU  - Murakami Y
FAU - Ishikawa, Y
AU  - Ishikawa Y
FAU - Yanaihara, N
AU  - Yanaihara N
FAU - Imura, H
AU  - Imura H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Peptides)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - 88813-36-9 (Galanin)
RN  - 9002-62-4 (Prolactin)
SB  - IM
MH  - Animals
MH  - Galanin
MH  - Hypothalamus/drug effects/physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Peptides/*pharmacology
MH  - Pituitary Gland/*drug effects/metabolism
MH  - Prolactin/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Vasoactive Intestinal Peptide/*physiology
EDAT- 1987/03/20 00:00
MHDA- 1987/03/20 00:01
CRDT- 1987/03/20 00:00
PHST- 1987/03/20 00:00 [pubmed]
PHST- 1987/03/20 00:01 [medline]
PHST- 1987/03/20 00:00 [entrez]
AID - 0304-3940(87)90073-5 [pii]
AID - 10.1016/0304-3940(87)90073-5 [doi]
PST - ppublish
SO  - Neurosci Lett. 1987 Mar 20;75(1):49-54. doi: 10.1016/0304-3940(87)90073-5.