PMID- 24376113
OWN - NLM
STAT- MEDLINE
DCOM- 20150115
LR  - 20211021
IS  - 1860-7187 (Electronic)
IS  - 1860-7179 (Print)
IS  - 1860-7179 (Linking)
VI  - 9
IP  - 6
DP  - 2014 Jun
TI  - A single subexcitation-energy electron can induce a double-strand break in DNA 
      modified by platinum chemotherapeutic drugs.
PG  - 1145-9
LID - 10.1002/cmdc.201300462 [doi]
AB  - The sensitization of malignant cells to ionizing radiation is the clinical 
      rationale for the use of platinum-drug-based concurrent chemoradiotherapy (CCRT) 
      for cancer treatment; however, the specific mechanisms of radiosensitization and 
      their respective contributions still remain unknown. Biological mechanisms such 
      as inhibition of DNA repair may contribute to the efficacy of CCRT; nevertheless, 
      there is a dearth of information on the possible contribution of nanoscopic 
      mechanisms to the generation of lethal DNA lesions, such as double-strand breaks 
      (DSB). The present study demonstrates that the abundant near zero-eV (0.5 eV) 
      electrons, created by ionizing radiation during radiotherapy, induce DSB in 
      supercoiled plasmid DNA modified by platinum-containing anticancer drugs (Pt 
      drugs), but not in unmodified DNA. They do so more efficiently than other types 
      of radiation, including soft X-rays and 10 eV electrons. The formation of DSB by 
      0.5 eV electrons is found to be a single-hit process. These findings reveal 
      insights into the radiosensitization mechanism of Pt drugs that can have 
      implications for the development of optimal clinical protocols for platinum-based 
      CCRT and the deployment of in situ sources of subexcitation-energy electrons 
      (e.g., Auger electron-emitting radionuclides) to efficiently enhance DSB 
      formation in DNA modified by Pt drugs in malignant cells.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Rezaee, Mohammad
AU  - Rezaee M
AD  - Department of Nuclear Medicine & Radiobiology, Faculty of Medicine & Health 
      Sciences, University of Sherbrooke, 3001, 12e Ave. Nord, Sherbrooke, QC, J1H 5N4 
      (Canada). Mohammad.Rezaee@USherbrooke.ca.
FAU - Alizadeh, Elahe
AU  - Alizadeh E
FAU - Cloutier, Pierre
AU  - Cloutier P
FAU - Hunting, Darel J
AU  - Hunting DJ
FAU - Sanche, Leon
AU  - Sanche L
LA  - eng
GR  - 81356-2/Canadian Institutes of Health Research/Canada
GR  - MOP86676/CAPMC/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131204
PL  - Germany
TA  - ChemMedChem
JT  - ChemMedChem
JID - 101259013
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Coordination Complexes)
RN  - 49DFR088MY (Platinum)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Antineoplastic Agents/*chemistry/therapeutic use/toxicity
MH  - Coordination Complexes/*chemistry/toxicity
MH  - DNA/chemistry/*metabolism
MH  - DNA Breaks, Double-Stranded/drug effects/radiation effects
MH  - Electrons
MH  - Humans
MH  - Neoplasms/drug therapy/radiotherapy
MH  - Plasmids/chemistry/metabolism
MH  - Platinum/*chemistry
MH  - *Radiation, Ionizing
PMC - PMC4623762
MID - CAMS5263
OID - NLM: CAMS5263
OTO - NOTNLM
OT  - DNA damage
OT  - chemoradiation therapy
OT  - cisplatin
OT  - low-energy electrons
OT  - platinum drugs
OT  - radiosensitization
EDAT- 2014/01/01 06:00
MHDA- 2015/01/16 06:00
PMCR- 2015/10/28
CRDT- 2013/12/31 06:00
PHST- 2013/11/13 00:00 [received]
PHST- 2013/12/31 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2015/01/16 06:00 [medline]
PHST- 2015/10/28 00:00 [pmc-release]
AID - 10.1002/cmdc.201300462 [doi]
PST - ppublish
SO  - ChemMedChem. 2014 Jun;9(6):1145-9. doi: 10.1002/cmdc.201300462. Epub 2013 Dec 4.