PMID- 24377157
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20191112
IS  - 0250-636X (Print)
IS  - 0250-636X (Linking)
VI  - 34
IP  - 2
DP  - 2013 Apr-Jun
TI  - Ilaprazole: Is this a superior proton pump inhibitor for duodenal ulcer?
PG  - 95-8
AB  - BACKGROUND: Preclinical studies have found ilaprazole to be significantly 
      effective in preventing the development of reflux oesophagitis and gastric 
      secretion in a dose-dependent manner; the drug also has a broad dose range and 
      safety feature. Till date only one clinical study on patients with 
      gastro-oesophageal reflux disease has shown its potency in suppressing gastric 
      acid secretion. OBJECTIVES: To review the published randomized controlled trials 
      (RCTs) assessing the efficacy of ilaprazole in duodenal ulcer (DU) compared to 
      other available proton pump inhibitors (PPI). METHODS: RCTs comparing ilaprazole 
      with other PPIs in DU were searched in the PubMed and Cochrane Library database 
      using the term 'ilaprazole and duodenal ulcer'. All clinical studies showing 
      effectiveness of ilaprazole in patients with DU, either full texts or scientific 
      abstracts and found to be potentially eligible for the systematic review, were 
      included and evaluated. RESULTS: Four RCTs having follow-up data were included. A 
      total of 1077 patients with DU were assessed. All the trials had included 
      omeprazole as a comparator PPI. The majority of patients (80%) became 
      asymptomatic after treatment in both the groups. None of the trials data predict 
      ilaprazole to be superior to omeprazole in terms of efficacy in patients with DU. 
      CONCLUSION: The trials conducted were limited in numbers and all the trial data 
      indicated the efficacy of ilaprazole to be similar to that of omeprazole. None of 
      the trials indicated superiority of ilaprazole over the existing PPIs.
FAU - Bohidar, N P
AU  - Bohidar NP
AD  - Gastroenterology and Hepatology, Rabindranath Tagore International Institute of 
      Cardiac Sciences, Kolkata, West Bengal, India. nbohidar@hotmail.com
FAU - Krishna, K
AU  - Krishna K
AD  - Department of Medicine, Bharati Vidyapeeth Medical College and Hospital, India.
FAU - Panda, B K
AU  - Panda BK
AD  - Department of Clinical Pharmacy (Pharm D programme), Poona College of Pharmacy, 
      Bharati Vidyapeeth Deemed University, India.
FAU - Patel, C
AU  - Patel C
AD  - D Pharm, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune, 
      Maharashtra, India.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - India
TA  - Trop Gastroenterol
JT  - Tropical gastroenterology : official journal of the Digestive Diseases Foundation
JID - 8107122
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - 776Q6XX45J (ilaprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/*therapeutic use
MH  - Duodenal Ulcer/*drug therapy
MH  - Humans
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Randomized Controlled Trials as Topic
EDAT- 2014/01/01 06:00
MHDA- 2014/01/24 06:00
CRDT- 2014/01/01 06:00
PHST- 2014/01/01 06:00 [entrez]
PHST- 2014/01/01 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
AID - 10.7869/tg.2012.105 [doi]
PST - ppublish
SO  - Trop Gastroenterol. 2013 Apr-Jun;34(2):95-8. doi: 10.7869/tg.2012.105.